Protective effects of subchronic caffeine administration on cisplatin induced urogenital toxicity in male mice

被引：0
|
作者：
Khazaei, M. [1 ]
Bayat, P. D. [2 ]
Ghanbari, A. [1 ]
Khazaei, S. [1 ]
Feizian, M. [3 ]
Khodaei, A. [3 ]
Alian, H. A. S. [3 ]
机构：
[1] Kermanshah Univ Med Sci, Fertil & Infertil Res Ctr, Kermanshah, Iran
[2] Arak Univ Med Sci, Dept Anat, Arak, Iran
[3] Kermanshah Univ Med Sci, Student Res Comm, Kermanshah, Iran
来源：
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY | 2012年 / 50卷 / 09期
关键词：
Apoptosis; Caffeine; Cisplatin; Mice; TUNEL; GERM-CELL APOPTOSIS; ACUTE-RENAL-FAILURE; INDUCED NEPHROTOXICITY; TESTICULAR DAMAGE; OXIDATIVE STRESS; DIETARY CAFFEINE; RAT TESTIS; SPERMATOGENESIS; PROCARBAZINE; CANCER;
D O I：
暂无
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
In Cisplatin treated group, the degeneration intensity of the kidneys the diameter of seminiferous tubules as well as the apoptotic index in testes and kidney were increased. In Caffeine+Cisplatin treated groups, the total body weight, the weight of testes and kidneys and also the histopathological data did not show significant differences. The motility of sperm in cisplatin group reduced but in Caffeine+Cisplatin groups this parameter was increased. These data suggest that caffeine recovers toxicity induced by cisplatin in both kidneys and testes of mice.
引用
收藏
页码：638 / 644
页数：7
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