Cell Adhesion and Activity Controlled by Titanate Nanowire

There's no dispute that the control of interaction between cell and implant including drug delivery system and biosensor is a long-purchased goal. Recently, scientists are looking forward to-exploring new materials in restricting cell adhesion and activity. In this paper, titanate nanowire was formed on the surface of titanium disks by hydrothermal route and the interaction between titanate nanowire and MG63 osteoblasts (including cell adhesion, proliferation and differentiation) was investigated. Results show that fewer cells are adhered on the smooth titanium disks than the nanowires. Only a few cells are fixed on the nanowire surface which exhibits an irregular long spindle shape observed by SEM. Immunofluoresense also illustrates an irregular cell shape without forming a cell structure, and the proliferation is restricted at the same time. Meanwhile, alkaline phosphatase and RUNX2 activity test share the same results. It can be well concluded that cell adhesion and activity is seriously restricted on the titanate nanowire surface. Such results can be applied on the further studies of drug delivery system and biosensor.