Isolation and characterization of wild type yellow fever virus in cases temporally associated with 17DD vaccination during an outbreak of yellow fever in Brazil

被引：8
|
作者：
de Filippis, AM
Nogueira, RMR
Jabor, AV
Schatzmayr, HG
Oliveira, JC
Dinis, SCD
Galler, R
机构：
[1] Fiocruz MS, Inst Oswaldo Cruz, Dept Virol, Lab Flavivurs, BR-21045900 Rio De Janeiro, RJ, Brazil
[2] Fiocruz MS, Inst Oswaldo Cruz, Dept Bioquim & Biol Mol, BR-21045900 Rio De Janeiro, RJ, Brazil
[3] Fiocruz MS, Inst Oswaldo Cruz, Hosp Evandro Chagas, Lab Patol, BR-21045900 Rio De Janeiro, RJ, Brazil
[4] Fundacao Ezequiel Dias, Lab Sorol, Belo Horizonte, MG, Brazil
来源：
VACCINE | 2004年 / 22卷 / 9-10期
关键词：
17DD yellow fever vaccine; vaccine associated; molecular characterization;
D O I：
10.1016/j.vaccine.2003.11.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A mass vaccination was carried out in the state of Minas Gerais, Southeast region of Brazil, to control an outbreak of sylvatic yellow fever in 2001. During the outbreak the surveillance system identified two fatal cases temporally associated with YF vaccination. Virus recovered from blood and postmortem samples of both cases was identified as yellow fever virus. Partial nucleotide sequence of parts of prM/E and the non-structural (NS) 5 genes and 3' non-coding region (3' NCR) was employed to characterize the origin of yellow fever virus (YFV) involved in both cases. Wild-type YFV was identified as the etiologic agent responsible for the disease. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1073 / 1078
页数：6
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