Convenient Synthesis and Characterization of Hydrazone Derivatives of 3-(2-Naphthyl)-1-phenyl-pyrazole-4-carbaldehyde

In order to obtain novel hydrazone derivatives containing pyrazole and thiazole rings which possess certain biological activity, a series of 1-(3-beta-naphthyl-1-phenylpyrazole-4-methylene)-2-(4-arylthiazol-2-yl)hydrazones were synthesized via two different methods including multi step reactions and one-pot synthetic route using 3-beta-naphthyl-1-phenyl-pyrazole-4-carbaldehyde as a starting intermediate. The products were obtained in good yield under ultrasonic irradiation condition rather than heating. The structures of products were characterized by H-1 NMR, MS and elemental analysis. The preliminary bioassay showed that compounds 4b and 4d possess obvious protective effects on the PC12 cells injury induced by H2O2.