Synthesis and tritium labelling of 6 beta-amino-4,5 alpha-epoxymorphinans and their 14-hydroxy derivatives as potential affinity labelling probes with mu opioid agonist activity

被引：5
|
作者：
Otvos, F
Toth, G
Lovas, S
Simon, C
Hosztafi, S
机构：
[1] ALKALOIDA CHEM CO LTD,H-4440 TISZAVASVARI,HUNGARY
[2] HUNGARIAN ACAD SCI,BIOL RES CTR,ISOTOPE LAB,H-6701 SZEGED,HUNGARY
来源：
HELVETICA CHIMICA ACTA | 1996年 / 79卷 / 01期
关键词：
D O I：
10.1002/hlca.19960790114
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of 6 beta-(methylfumaramido) and 6 beta-chloroacetamido derivatives 1b and 1c of 6 beta-amino-7,8-didehydromorphinan and the corresponding 14-hydroxy derivatives le and If are described. The 7,8-dihydro derivatives of these compounds were synthesized in inactive (2b, c, e, f) as well as in tritiated form (3b, c,e, f).
引用
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页码：133 / 136
页数：4
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