Palladium-Catalyzed Electrochemical C-H Alkylation of Arenes

被引：39

作者：

Yang, Qi-Liang ^{[1
,2
,3
]}

Li, Chuan-Zeng ^{[3
,4
]}

Zhang, Liang-Wei ^{[3
]}

Li, Yu-Yan ^{[4
]}

Tong, Xiaofeng ^{[1
,2
]}

Wu, Xin-Yan ^{[1
,2
]}

Mei, Tian-Sheng ^{[3
]}

机构：

[1] East China Univ Sci & Technol, Key Lab Adv Mat, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

[2] East China Univ Sci & Technol, Inst Fine Chem, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China

[3] Chinese Acad Sci, State Key Lab Organometall Chem, Ctr Excellence Mol Synth, Shanghai Inst Organ Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

[4] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Jiangsu, Peoples R China

来源：

ORGANOMETALLICS | 2019年 / 38卷 / 06期

关键词：

CROSS-COUPLING REACTIONS; ALKYLBORONIC ACIDS; BONDS; C(SP(2))-H; FUNCTIONALIZATION; ARYLATION; REAGENTS; ARYL; ACETOXYLATION; BENZOQUINONE;

D O I：

10.1021/acs.organomet.8b00550

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Palladium-catalyzed electrochemical C-H functionalization reactions have emerged as attractive tools for organic synthesis. This process offers an alternative to conventional methods that require harsh chemical oxidants. However, this electrolysis requires divided cells to avoid catalyst deactivation by cathodic reduction. Herein, we report the first example of palladium-catalyzed electrochemical C-H alkylation of arenes using undivided electrochemical cells in water, thereby providing a practical solution for the introduction of alkyl groups into arenes.

引用

页码：1208 / 1212

页数：5

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