Beside the MEF2 axis: Unconventional functions of HDAC4

被引：33
|
作者：
Clocchiatti, Andrea [1 ,2 ]
Di Giorgio, Eros [1 ,2 ]
Demarchi, Francesca [3 ]
Brancolini, Claudio [1 ,2 ]
机构：
[1] Univ Udine, Dipartimento Sci Med & Biol, I-33100 Udine, Italy
[2] Univ Udine, MATI Ctr Excellence, I-33100 Udine, Italy
[3] Lab Nazl CIB, I-34012 Trieste, Italy
来源：
CELLULAR SIGNALLING | 2013年 / 25卷 / 01期
关键词：
Histone deacetylase; MEF2; HIF; STAT1; FOXOs; Foxp3; Sumoylation; Metabolism; Muscle; LXB; II HISTONE DEACETYLASES; CONTROLS CHONDROCYTE HYPERTROPHY; FOXO TRANSCRIPTION FACTORS; GENE-EXPRESSION; MUSCLE ATROPHY; HYPOXIA; ACETYLATION; BINDING; ACTIVATION; PROMOTES;
D O I：
10.1016/j.cellsig.2012.10.002
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The class Ila deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF2s. At the same time, pieces of evidence have gradually accumulated about HDAC4 activities emancipated from MEF2s. The aim of this review is to discuss about these "unconventional functions" of HDAC4. (C) 2012 Elsevier Inc. All rights reserved.
引用
收藏
页码：269 / 276
页数：8
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