Advances in kidney-targeted drug delivery systems

被引：19
|
作者：
Chen, Zhong [1 ]
Peng, Haisheng [1 ]
Zhang, Changmei [1 ]
机构：
[1] Harbin Med Univ, Dept Pharmaceut, Daqing Campus,1 Xinyang Rd, Daqing 163319, Peoples R China
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2020年 / 587卷
关键词：
Kidney; Target; Nanomedicine; Drug delivery systems; MOLECULAR-WEIGHT CHITOSAN; MESANGIAL CELLS; MANNOSE RECEPTOR; RENAL FIBROSIS; GLOMERULAR BARRIER; ENDOTHELIAL-CELLS; CONJUGATE; NANOPARTICLES; MECHANISMS; PEPTIDE;
D O I：
10.1016/j.ijpharm.2020.119679
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The management and treatment of kidney diseases currently have caused a huge global burden. Although the application of nanotechnology for the therapy of kidney diseases is still at an early stages, it has profound potential of development. More and more nano-based drug delivery systems provide novel solutions for the treatment of kidney diseases. This article summarizes the physiological and anatomical properties of the kidney and the biological and physicochemical characters of drug delivery systems, which affects the ability of drug to target the kidney, and highlights the prospects, opportunities, and challenges of nanotechnology in the therapy of kidney diseases.
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页数：11
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