Poly (vinyl alcohol) Microspheres Sandwiched Poly (3-hydroxybutyric acid) Electrospun Fibrous Scaffold for Tissue Engineering and Drug Delivery

被引：13
|
作者：
Nagiah, Naveen [1 ]
Ramanathan, Giriprasath [1 ]
Sobhana, Liji [1 ]
Sivagnanam, Uma Tirichurapalli [1 ]
Srinivasan, Natarajan Tirupattur [2 ]
机构：
[1] Cent Leather Res Inst, Biomat Div, Bioprod Lab, Madras 600020, Tamil Nadu, India
[2] Indian Inst Technol Madras, Dept Phys, Conducting Polymers Lab, Madras, Tamil Nadu, India
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2014年 / 63卷 / 11期
关键词：
electrospinning; Biomaterials; drug delivery; wound dressing; NANOFIBERS;
D O I：
10.1080/00914037.2013.854230
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Three drug delivery systems viz. doxycycline hyclate entrapped poly (vinyl alcohol) (PVA) microspheres (DM), composite fibers of doxycycline hyclatepoly (3-hydroxybutyric acid) (PHB) electrospun fibers (DF), and doxycycline hyclateloaded poly (vinyl alcohol) (PVA) microspheres sandwiched between composite fibers consisting of poly (3-hydroxybutyric acid) (PHB) and doxycycline hyclate (DMF), were developed. The initial burst release studies revealed that DMF drug delivery system developed through suspension electrospinning possessed an optimal initial burst release for wound healing. The developed scaffolds will potentially function in mimicking the extracellular matrix and consecutively enhance healing through its optimal drug release thereby proving its mettle as potential wound dressings for skin regeneration.
引用
收藏
页码：583 / 585
页数：3
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