Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators

被引：9

作者：

Griebenow, Nils ^{[1
]}

Schirok, Hartmut ^{[1
]}

Mittendorf, Joachim ^{[1
]}

Straub, Alexander ^{[1
]}

Follmann, Markus ^{[1
]}

Stasch, Johannes-Peter ^{[2
]}

Knorr, Andreas ^{[2
]}

Schlemmer, Karl-Heinz ^{[3
]}

Redlich, Gorden ^{[3
]}

机构：

[1] Bayer Pharma AG, Global Drug Discovery, Med Chem Wuppertal, D-42096 Wuppertal, Germany

[2] Bayer Pharma AG, Global Drug Discovery, Cardiol Res, D-42096 Wuppertal, Germany

[3] Bayer Pharma AG, Global Drug Discovery, Res Pharmacokinet, D-42096 Wuppertal, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 05期

关键词：

Guanylate cyclase; Stimulator; Acidic heterocycles; Carboxylic acid isosteres; SAR; DESIGN; POTENT;

D O I：

10.1016/j.bmcl.2013.01.028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1197 / 1200

页数：4

共 50 条

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[2] 1H-PYRAZOLO[3,4-B]PYRIDINES
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[4] A Multicomponent Approach to Highly Substituted 1H-Pyrazolo[3,4-b]pyridines
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[J]. SYNTHESIS-STUTTGART, 2016, 48 (14): : 2201 - 2204
[5] Discovery of 3-(2-pyrimidinyl)pyrazolo[3,4-b]pyridines as NO-independent stimulators of soluble guanylate cyclase.
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[6] 1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
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[7] Photophysical properties of derivatives of 1H-pyrazolo[3,4-b]quinoline and 1H-pyrazolo[3,4-b]quinoxaline
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[8] 1H-pyrazolo[3,4-b]quinoline and 1H-pyrazolo[3,4-b]quinoxaline derivatives as promising materials for optoelectronic applications
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[9] SYNTHESIS OF SOME NEW FLUORINE CONTAINING 1H-PYRAZOLO[3,4-B]PYRIDINES
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