DNA methylation changes in epithelial ovarian cancer histotypes

被引:44
|
作者
Earp, Madalene A. [1 ]
Cunningham, Julie M. [2 ]
机构
[1] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA
[2] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA
关键词
Ovarian cancer; Histotypes; Methylation; CLEAR-CELL CARCINOMA; GENE PROMOTER METHYLATION; ACQUIRED CISPLATIN RESISTANCE; PLATINUM-BASED CHEMOTHERAPY; PROGRESSION-FREE SURVIVAL; SEROUS BORDERLINE TUMORS; GENOME-WIDE ASSOCIATION; POOR-PROGNOSIS; SUSCEPTIBILITY LOCI; DRUG-RESISTANCE;
D O I
10.1016/j.ygeno.2015.09.001
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Survival after a diagnosis of ovarian cancer has not improved, and despite histological differences, treatment is similar for all cases. Understanding the molecular basis for ovarian cancer risk and prognosis is fundamental, and to this end much has been gleaned about genetic changes contributing to risk, and to a lesser extent, survival. There's considerable evidence for genetic differences between the four pathologically defined histological sub-types; however, the contribution of epigenetics is less well documented. In this report, we review alterations in DNA methylation in ovarian cancer, focusing on histological subtypes, and studies examining the roles of methylation in determining therapy response. As epigenetics is making its way into clinical care, we review the application of cell free DNA methylation to ovarian cancer diagnosis and care. Finally, we comment on recurrent limitations in the DNA methylation literature for ovarian cancer, which can and should be addressed to mature this field. (C) 2015 Elsevier Inc. All rights reserved.
引用
收藏
页码:311 / 321
页数:11
相关论文
共 50 条
  • [1] DNA Methylation as a Robust Classifier of Epithelial Ovarian Cancer
    Ishak, Charles A.
    Lheureux, Stephanie
    De Carvalho, Daniel D.
    [J]. CLINICAL CANCER RESEARCH, 2019, 25 (19) : 5729 - 5731
  • [2] DNA methylation changes during epithelial-to-mesenchymal transition in ovarian cancer cells
    Cardenas, Horacio
    Vieth, Edyta
    Lee, Jiyoon
    Liu, Yunlong
    Nephew, Kenneth P.
    Matei, Daniela
    [J]. CLINICAL CANCER RESEARCH, 2015, 21
  • [3] Correlation of Smoking-Associated DNA Methylation Changes in Buccal Cells With DNA Methylation Changes in Epithelial Cancer
    Teschendorff, Andrew E.
    Yang, Zhen
    Wong, Andrew
    Pipinikas, Christodoulos P.
    Jiao, Yinming
    Jones, Allison
    Anjum, Shahzia
    Hardy, Rebecca
    Salvesen, Helga B.
    Thirlwell, Christina
    Janes, Samuel M.
    Kuh, Diana
    Widschwendter, Martin
    [J]. JAMA ONCOLOGY, 2015, 1 (04) : 476 - 485
  • [4] Mediation analysis of alcohol consumption, DNA methylation, and epithelial ovarian cancer
    Dongyan Wu
    Haitao Yang
    Stacey J. Winham
    Yanina Natanzon
    Devin C. Koestler
    Tiane Luo
    Brooke L. Fridley
    Ellen L. Goode
    Yanbo Zhang
    Yuehua Cui
    [J]. Journal of Human Genetics, 2018, 63 : 339 - 348
  • [5] Mediation analysis of alcohol consumption, DNA methylation, and epithelial ovarian cancer
    Wu, Dongyan
    Yang, Haitao
    Winham, Stacey J.
    Natanzon, Yanina
    Koestler, Devin C.
    Luo, Tiane
    Fridley, Brooke L.
    Goode, Ellen L.
    Zhang, Yanbo
    Cui, Yuehua
    [J]. JOURNAL OF HUMAN GENETICS, 2018, 63 (03) : 339 - 348
  • [6] DNA Methylation in Epithelial Ovarian Cancer: Current Data and Future Perspectives
    Papakonstantinou, Efthymia
    Androutsopoulos, Georgios
    Logotheti, Souzana
    Adonakis, Georgios
    Maroulis, Ioannis
    Tzelepi, Vassiliki
    [J]. CURRENT MOLECULAR PHARMACOLOGY, 2021, 14 (06) : 1013 - 1027
  • [7] DNA methylation characteristics associated with chemotherapy resistance in epithelial ovarian cancer
    Duan, Changling
    Yan, Zhongxin
    Wu, Cailiang
    Zhou, Xuexin
    Bao, Wei
    [J]. HELIYON, 2024, 10 (05)
  • [8] DNA methylation in ovarian cancer - II. Expression of DNA methyltransferases in ovarian cancer cell lines and normal ovarian epithelial cells
    Ahluwalia, A
    Hurteau, JA
    Bigsby, RM
    Nephew, KP
    [J]. GYNECOLOGIC ONCOLOGY, 2001, 82 (02) : 299 - 304
  • [9] DNA methylation in ovarian cancer
    Strathdee, G
    Appleton, K
    Plumb, J
    Brown, R
    [J]. BRITISH JOURNAL OF CANCER, 2001, 85 : 18 - 18
  • [10] DNA methylation in ovarian cancer
    Koukoura, Ourania
    Daponte, Alexandros
    Sifakis, Stavros
    Spandidos, Demetrios A.
    [J]. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2016, 38 : S61 - S61