Dopamine signaling in the medial prefrontal cortex and amygdala is required for the acquisition of fructose-conditioned flavor preferences in rats

被引:32
|
作者
Malkusz, Danielle C. [2 ]
Banakos, Theodore [1 ]
Mohamed, Andrew [1 ]
Vongwattanakit, Tracy [1 ]
Malkusz, Gina [1 ]
Saeed, Shermeen [1 ]
Martinez, Stewart [1 ]
Bohn, Tara [1 ]
Mahmud, Fizza [1 ]
Liss, Cami [1 ]
Rozvi, Abraham [1 ]
Touzani, Khalid [4 ]
Sclafani, Anthony [2 ,3 ,4 ]
Bodnar, Richard J. [1 ,2 ]
机构
[1] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA
[2] CUNY, Grad Ctr, Neuropsychol Doctoral Subprogram, New York, NY USA
[3] CUNY, Grad Ctr, Cognit Brain & Behav Doctoral Subprogram, New York, NY USA
[4] CUNY Brooklyn Coll, Dept Psychol, New York, NY USA
关键词
Flavor-flavor learning; Sweet taste; Saccharin; SCH23390; Raclopride; Nucleus accumbens shell; NUCLEUS-ACCUMBENS DOPAMINE; SHAM-FEEDING RATS; TOPOGRAPHICAL ORGANIZATION; RECEPTOR ANTAGONISTS; D1-LIKE RECEPTORS; GLUCOSE; EXPRESSION; SUCROSE; PROJECTIONS; CONSUMPTION;
D O I
10.1016/j.bbr.2012.05.004
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Systemic administration of dopamine (DA) D1 (SCH23390: SCH) and D2 (raclopride: RAC) antagonists blocked both acquisition and expression of fructose-conditioned flavor preferences (CFP). It is unclear what brain circuits are involved in mediating these effects. The present study investigated DA signaling within the nucleus accumbens shell (NAcS), amygdala (AMY) and medial prefrontal cortex (mPFC) in the acquisition and expression of fructose-CFP. In Experiment 1, separate groups of rats were injected daily in the NAcS or AMY with saline, SCH (24 nmol) or RAC (24 nmol) prior to training sessions with a flavor (CS+) mixed with 8% fructose and 0.2% saccharin (CS+/F) and a different flavor (CS-) mixed with only 0.2% saccharin. In the two-bottle choice tests with 0.2% saccharin, only rats injected with RAC in the AMY failed to acquire a CS+ preference (45-54%). In Experiment 2, new rats were identically trained, but saline, SCH and RAC were injected in the mPFC. In subsequent two-bottle choice tests, SCH- and RAC-treated rats failed to exhibit a CS+ preference (50-56%). In Experiment 3, new rats were trained with CS+/F and CS- without injections. Subsequent two-bottle choice tests were then conducted following bilateral injections of SCH or RAC in the mPFC at total doses of 0, 12, 24 and 48 nmol. Expression of the CS+ preference failed to be affected by either antagonist, indicating that the mPFC is not involved in the maintenance of this preference. These data indicate that the acquisition of fructose-CFP is dependent on DA signaling in the mPFC and AMY. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码:500 / 507
页数:8
相关论文
共 50 条
  • [1] Dopamine receptor signaling in the medial orbital frontal cortex and the acquisition and expression of fructose-conditioned flavor preferences in rats
    Malkusz, Danielle C.
    Yenko, Ira
    Rotella, Francis M.
    Banakos, Theodore
    Olsson, Kerstin
    Dindyal, Trisha
    Vig, Vishal
    Bodnar, Richard J.
    [J]. BRAIN RESEARCH, 2015, 1596 : 116 - 125
  • [2] Evaluation of saccharin intake and expression of fructose-conditioned flavor preferences following opioid receptor antagonism in the medial prefrontal cortex, amygdala or lateral hypothalamus in rats
    Malkusz, Danielle C.
    Bernal, Sonia Y.
    Banakos, Theodore
    Malkusz, Gina
    Mohamed, Andrew
    Vongwattanakit, Tracy
    Bodnar, Richard J.
    [J]. NEUROSCIENCE LETTERS, 2014, 564 : 94 - 98
  • [3] Role of amygdala dopamine D1 and D2 receptors in the acquisition and expression of fructose-conditioned flavor preferences in rats
    Bernal, Sonia
    Miner, Patricia
    Abayev, Yana
    Kandova, Ester
    Gerges, Meri
    Touzani, Khalid
    Sclafani, Anthony
    Bodnar, Richard J.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2009, 205 (01) : 183 - 190
  • [4] GLUCOSE-CONDITIONED AND FRUCTOSE-CONDITIONED FLAVOR PREFERENCES IN RATS - TASTE VERSUS POSTINGESTIVE CONDITIONING
    SCLAFANI, A
    ACKROFF, K
    [J]. PHYSIOLOGY & BEHAVIOR, 1994, 56 (02) : 399 - 405
  • [5] Role of systemic endocannabinoid CB-1 receptor antagonism in the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats
    Miner, Patricia
    Abayev, Yana
    Kandova, Ester
    Gerges, Meri
    Styler, Esther
    Wapniak, Rachel
    Touzani, Khalid
    Sclafani, Anthony
    Bodnar, Richard J.
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2008, 90 (03) : 318 - 324
  • [6] Role of dopamine D1 and D2 receptors in the nucleus accumbens shell on the acquisition and expression of fructose-conditioned flavor-flavor preferences in rats
    Bernal, Sonia Y.
    Dostova, Irina
    Kest, Asher
    Abayev, Yana
    Kandova, Ester
    Touzani, Khalid
    Sclafani, Anthony
    Bodnar, Richard J.
    [J]. BEHAVIOURAL BRAIN RESEARCH, 2008, 190 (01) : 59 - 66
  • [7] Strain differences in sucrose- and fructose-conditioned flavor preferences in mice
    Pinhas, Alexander
    Aviel, Michael
    Koen, Michael
    Gurgov, Simon
    Acosta, Vanessa
    Israel, Michael
    Kakuriev, Leonid
    Guskova, Elena
    Fuzailov, Isabelle
    Touzani, Khalid
    Sclafani, Anthony
    Bodnar, Richard J.
    [J]. PHYSIOLOGY & BEHAVIOR, 2012, 105 (02) : 451 - 459
  • [8] Fructose-conditioned flavor preferences in male and female rats: effects of sweet taste and sugar concentration
    Ackroff, K
    Sclafani, A
    [J]. APPETITE, 2004, 42 (03) : 287 - 297
  • [9] Baclofen differentially mediates fructose-conditioned flavor preference and quinine-conditioned flavor avoidance in rats
    Rotella, Francis M.
    Vig, Vishal
    Olsson, Kerstin
    Pagirsky, Jeremy
    Aminov, Alon
    Kohen, Ilanna
    Bodnar, Richard J.
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2016, 775 : 15 - 21
  • [10] Naltrexone does not prevent acquisition or expression of flavor preferences conditioned by fructose in rats
    Baker, RW
    Li, Y
    Lee, MG
    Sclafani, A
    Bodnar, RJ
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2004, 78 (02) : 239 - 246