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Dopamine signaling in the medial prefrontal cortex and amygdala is required for the acquisition of fructose-conditioned flavor preferences in rats
被引:32
|作者:
Malkusz, Danielle C.
[2
]
Banakos, Theodore
[1
]
Mohamed, Andrew
[1
]
Vongwattanakit, Tracy
[1
]
Malkusz, Gina
[1
]
Saeed, Shermeen
[1
]
Martinez, Stewart
[1
]
Bohn, Tara
[1
]
Mahmud, Fizza
[1
]
Liss, Cami
[1
]
Rozvi, Abraham
[1
]
Touzani, Khalid
[4
]
Sclafani, Anthony
[2
,3
,4
]
Bodnar, Richard J.
[1
,2
]
机构:
[1] CUNY Queens Coll, Dept Psychol, Flushing, NY 11367 USA
[2] CUNY, Grad Ctr, Neuropsychol Doctoral Subprogram, New York, NY USA
[3] CUNY, Grad Ctr, Cognit Brain & Behav Doctoral Subprogram, New York, NY USA
[4] CUNY Brooklyn Coll, Dept Psychol, New York, NY USA
关键词:
Flavor-flavor learning;
Sweet taste;
Saccharin;
SCH23390;
Raclopride;
Nucleus accumbens shell;
NUCLEUS-ACCUMBENS DOPAMINE;
SHAM-FEEDING RATS;
TOPOGRAPHICAL ORGANIZATION;
RECEPTOR ANTAGONISTS;
D1-LIKE RECEPTORS;
GLUCOSE;
EXPRESSION;
SUCROSE;
PROJECTIONS;
CONSUMPTION;
D O I:
10.1016/j.bbr.2012.05.004
中图分类号:
B84 [心理学];
C [社会科学总论];
Q98 [人类学];
学科分类号:
03 ;
0303 ;
030303 ;
04 ;
0402 ;
摘要:
Systemic administration of dopamine (DA) D1 (SCH23390: SCH) and D2 (raclopride: RAC) antagonists blocked both acquisition and expression of fructose-conditioned flavor preferences (CFP). It is unclear what brain circuits are involved in mediating these effects. The present study investigated DA signaling within the nucleus accumbens shell (NAcS), amygdala (AMY) and medial prefrontal cortex (mPFC) in the acquisition and expression of fructose-CFP. In Experiment 1, separate groups of rats were injected daily in the NAcS or AMY with saline, SCH (24 nmol) or RAC (24 nmol) prior to training sessions with a flavor (CS+) mixed with 8% fructose and 0.2% saccharin (CS+/F) and a different flavor (CS-) mixed with only 0.2% saccharin. In the two-bottle choice tests with 0.2% saccharin, only rats injected with RAC in the AMY failed to acquire a CS+ preference (45-54%). In Experiment 2, new rats were identically trained, but saline, SCH and RAC were injected in the mPFC. In subsequent two-bottle choice tests, SCH- and RAC-treated rats failed to exhibit a CS+ preference (50-56%). In Experiment 3, new rats were trained with CS+/F and CS- without injections. Subsequent two-bottle choice tests were then conducted following bilateral injections of SCH or RAC in the mPFC at total doses of 0, 12, 24 and 48 nmol. Expression of the CS+ preference failed to be affected by either antagonist, indicating that the mPFC is not involved in the maintenance of this preference. These data indicate that the acquisition of fructose-CFP is dependent on DA signaling in the mPFC and AMY. (C) 2012 Elsevier B.V. All rights reserved.
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页码:500 / 507
页数:8
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