Efficacy of live Chlamydophila abortus vaccine 1B in protecting mice placentas and foetuses against strains of Chlamydophila pecorum isolated from cases of abortion

被引：23
|
作者：
Rekiki, A
Bouakane, A
Hammami, S
El Idrissi, AH
Bernard, F
Rodolakis, A [1 ]
机构：
[1] INRA, Ctr Tours, Unite Pathol Infect & Immunol, F-37380 Nouzilly, France
[2] Inst Rech Vet, Tunis 1006, Tunisia
[3] FAO, Inst Agron & Vet Hassan 2, Anim Prod & Hlth Div, Rabat Inst, I-00100 Rome, Italy
来源：
VETERINARY MICROBIOLOGY | 2004年 / 99卷 / 3-4期
关键词：
small ruminants; abortion; chlamydiosis; Chlamydophila pecorum; vaccine;
D O I：
10.1016/j.vetmic.2004.01.010
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The efficacy of Chlamydophila abortus vaccine strain 1B in protecting against two selected Chlamydophila pecorum strains, isolated from an aborted goat (M14) in Morocco and a ewe (AB10) in France, was investigated in a mouse model, by comparing the reduction in number of bacteria in the placentas of vaccinated mice challenged intraperitoneally at 11 days of pregnancy with the reference C abortus (AB7) and C pecorum (M14, or AB10) strains, to those of unvaccinated mice. Vaccine 1B was shown to provide effective protection against the field strains of C. pecorum, since it significantly reduced the placental Chlamydophila colonisation. The two C. pecorum strains were not sufficiently abortifacient in mice to use reduction in abortion as a criterion of protection. (C) 2004 Published by Elsevier B.V.
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收藏
页码：295 / 299
页数：5
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