Effects of Pentoxifylline on Amikacin-Induced Nephrotoxicity in Rats

被引：27

作者：

Ozer, Mehmet Kaya ^{[1
]}

Asci, Halil ^{[1
]}

Oncu, Meral ^{[2
]}

Yesilot, Sukriye ^{[1
]}

Savran, Mehtap ^{[1
]}

Bayram, Dilek ^{[2
]}

Cicek, Ekrem ^{[1
]}

机构：

[1] Suleyman Demirel Univ, Dept Pharmacol, Fac Med, TR-32260 Isparta, Turkey

[2] Suleyman Demirel Univ, Dept Histol, Fac Med, TR-32260 Isparta, Turkey

来源：

RENAL FAILURE | 2009年 / 31卷 / 02期

关键词：

amikacin; renal injury; pentoxifylline; rat; TUMOR-NECROSIS-FACTOR; ACUTE-RENAL-FAILURE; FACTOR-ALPHA; PHOSPHODIESTERASE ISOZYMES; DIABETIC-PATIENTS; INHIBITORS; SUPPRESSION; GLOMERULONEPHRITIS; ANTIOXIDANT; DERIVATIVES;

D O I：

10.1080/08860220802595492

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The nephrotoxicity of amikacin (AK) was prevented with pentoxifylline (PTX) in a rat model. Rats were received a single injection of AK (1.2 g/kg, i.p.) with or without PTX pretreatment (25 mg/kg, orally). Renal morphology was investigated by light microscopy. Tissue samples and trunk blood were also obtained to determine renal malondialdehyde (MDA), blood urea nitrogen (BUN), and creatinine (Cr) levels. MDA production was found to be higher in AK group. PTX administration caused a significant decrease in MDA production. Morphological damage in rats given AK was severe in the kidney, whereas in rats given AK plus PTX, no histological changes occurred. It is concluded that PTX could be useful for reducing the nephrotoxic effects of AK.

引用

页码：134 / 139

页数：6

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