Advance in PUMA and Cardiomyocyte Apoptosis

被引：1

作者：

Li Yu-Zhen ^{[1
]}

Liu Xiu-Hua ^{[1
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Inst Basic Med Sci, Dept Pathophysiol, Beijing 100853, Peoples R China

来源：

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2012年 / 39卷 / 11期

基金：

中国国家自然科学基金;

关键词：

PUMA; cardiomyocyte apoptosis; pro-apoptotic protein; CARDIAC-FUNCTION; PROTEINS; DEATH; IDENTIFICATION; INHIBITION; MOLECULE; DELETION; BINDING; SIGNAL; GENE;

D O I：

10.3724/SP.J.1206.2011.00368

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

p53 upregulated modulator of apoptosis (PUMA) is a recently identified p53 target gene which can induce apoptosis. Compared with other p53 target genes, p53 has two important characteristics. One is that PUMA almost mediates all p53-dependent apoptotic signals. The other is that PUMA is not only required for p53-dependent apoptotic pathway, but also for p53-independent apoptosis. In cardiomyocytes, PUMA is involved in apoptosis induced by various stimulations such as ischemia/reperfusion, endoplasmic reticulum stress. Therefore, PUMA plays a pivotal role in cardiomyocyte apoptosis.

引用

页码：1045 / 1049

页数：5

共 38 条

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