Palladium(II)-Catalyzed Enantio- and Diastereoselective Synthesis of Pyrrolidine Derivatives

被引：81

作者：

Jana, Ranjan ^{[1
]}

Pathak, Tejas P. ^{[1
]}

Jensen, Katrina H. ^{[1
]}

Sigman, Matthew S. ^{[1
]}

机构：

[1] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA

来源：

ORGANIC LETTERS | 2012年 / 14卷 / 16期

基金：

美国国家卫生研究院;

关键词：

PALLADIUM-CATALYZED CARBOAMINATION; C-H ACTIVATION; PD(0)-CATALYZED DIAMINATION; AEROBIC DIALKOXYLATION; TERMINAL ALKENES; MOLECULAR-OXYGEN; DIFUNCTIONALIZATION; INHIBITORS; COMPLEXES; OXIDATION;

D O I：

10.1021/ol3016989

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed enantio- and diastereoselective synthesis of pyrrolidine derivatives is described. Initial intramolecular nucleopalladation of the tethered protected amine forms the pyrrolidine moiety and a quinone methide intermediate. A second nucleophile adds intermolecularly to afford diverse products in high enantio- and diastereoselectivity.

引用

页码：4074 / 4077

页数：4

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