Searching human brain for mechanisms of psychiatric disorders. Implications for studies on schizophrenia

被引：9

作者：

Berretta, Sabina ^{[1
,2
,3
]}

Heckers, Stephan ^{[4
]}

Benes, Francine M. ^{[2
,3
,5
]}

机构：

[1] McLean Hosp, Translat Neurosci Lab, Belmont, MA 02478 USA

[2] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Program Neurosci, Boston, MA 02115 USA

[4] Vanderbilt Univ, Dept Psychiat, Nashville, TN 37235 USA

[5] Program Struct & Mol Neurosci, Belmont, MA 02478 USA

来源：

SCHIZOPHRENIA RESEARCH | 2015年 / 167卷 / 1-3期

关键词：

Human postmortem; In vivo imaging; Confounding factors; Psychiatric disorders; Comorbidity; MESSENGER-RNA EXPRESSION; DORSOLATERAL PREFRONTAL CORTEX; ANTERIOR CINGULATE CORTEX; SUBSTANCE USE DISORDERS; BIPOLAR DISORDER; 1ST-EPISODE PSYCHOSIS; GABAERGIC DYSFUNCTION; NONPYRAMIDAL NEURONS; CORTICAL DYSFUNCTION; PARVALBUMIN NEURONS;

D O I：

10.1016/j.schres.2014.10.019

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

In the past 25 years, research on the human brain has been providing a clear path toward understanding the pathophysiology of psychiatric illnesses. The successes that have been accrued are matched by significant difficulties identifying and controlling a large number of potential confounding variables. By systematically and effectively accounting for unwanted variance in data from imaging and postmortem human brain studies, meaningful and reliable information regarding the pathophysiology of human brain disorders can be obtained. This perspective paper focuses on postmortem investigations to discuss some of the most challenging sources of variance, including diagnosis, comorbidity, substance abuse and pharmacological treatment, which confound investigations of the human brain. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：91 / 97

页数：7

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