Interactome overlap between risk genes of epilepsy and targets of anti-epileptic drugs

被引:0
|
作者
Lv, Yu-Qin [1 ]
Wang, Xing [1 ]
Jiao, Yu-Zhuang [2 ]
Wang, Yan-Hua [1 ]
Wang, Na [3 ]
Gao, Lei [4 ]
Zhang, Jing-Jun [5 ]
机构
[1] Shandong First Med Univ & Shandong Acad Med Sci, Sch Clin Med, Jinan, Shandong, Peoples R China
[2] Shandong First Med Univ, Shandong Prov Qianfoshan Hosp, Affiliated Hosp 1, Jinan, Shandong, Peoples R China
[3] Taishan Vocat Coll Nursing, Dept Internal Med, Tai An, Shandong, Peoples R China
[4] Shandong First Med Univ & Shandong Acad Med Sci, Sch Life Sci, Dept Bioinformat, Tai An, Shandong, Peoples R China
[5] Shandong First Med Univ, Dept Neurol, Affiliated Hosp 2, Tai An, Shandong, Peoples R China
来源
PLOS ONE | 2022年 / 17卷 / 08期
基金
中国国家自然科学基金;
关键词
GENETICS; PLATFORM; REVEALS; MOUSE; CELL;
D O I
10.1371/journal.pone.0272428
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Anti-epileptic drugs have been used for treating epilepsy for decades, meanwhile, more than one hundred genes have been identified to be associated with risk of epilepsy; however, the interaction mechanism between anti-epileptic drugs and risk genes of epilepsy was still not clearly understood. In this study, we systematically explored the interaction of epilepsy risk genes and anti-epileptic drug targets through a network-based approach. Our results revealed that anti-epileptic drug targets were significantly over-represented in risk genes of epilepsy with 17 overlapping genes and P-value = 2.2 x 10(-16). We identified a significantly localized PPI network with 55 epileptic risk genes and 94 anti-epileptic drug target genes, and network overlap analysis showed significant interactome overlap between risk genes and drug targets with P-value = 0.04. Besides, genes from PPI network were significantly enriched in the co-expression network of epilepsy with 22 enriched genes and P-value = 1.3 x 10(-15) ; meanwhile, cell type enrichment analysis indicated genes in this network were significantly enriched in 4 brain cell types (Interneuron, Medium Spiny Neuron, CA1 pyramidal Neuron, and Somatosensory pyramidal Neuron). These results provide evidence for significant interactions between epilepsy risk genes and anti-epileptic drug targets from the perspective of network biology.
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页数:13
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