Innate immunity modulation in virus entry

被引:33
|
作者
Faure, Mathias [1 ,2 ,3 ]
Rabourdin-Combe, Chantal [1 ,2 ,3 ]
机构
[1] Univ Lyon, Lyon, France
[2] INSERM, U851, F-69007 Lyon, France
[3] Univ Lyon 1, UMS3444, US8, F-69622 Villeurbanne, France
关键词
HEPATITIS-C VIRUS; INTERFERON REGULATORY FACTOR-3; MANNOSE-BINDING LECTIN; PROLYL ISOMERASE PIN1; LYMPHOCYTIC-CHORIOMENINGITIS-VIRUS; HERPES-SIMPLEX-VIRUS; TOLL-LIKE RECEPTORS; DENDRITIC CELLS; I INTERFERON; RIG-I;
D O I
10.1016/j.coviro.2011.05.013
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Entry into a cell submits viruses to detection by pattern recognition receptors (PRRs) leading to an early innate anti-viral response. Several viruses evolved strategies to avoid or subvert PRR recognition at the step of virus entry to promote infection. Whereas viruses mostly escape from soluble PRR detection, endocytic/phagocytic PRRs, such as the mannose receptor or DC-SIGN, are commonly used for virus entry. Moreover, virion-incorporated proteins may also offer viruses a way to dampen anti-viral innate immunity upon virus entry, and entering viruses might usurp autophagy to improve their own infectivity.
引用
收藏
页码:6 / 12
页数:7
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