Ovarian Tissue Cryopreservation and Novel Bioengineering Approaches for Fertility Preservation

被引:7
|
作者
Jones, Andrea S. K. [1 ]
Shikanov, Ariella [1 ,2 ,3 ]
机构
[1] Univ Michigan, Dept Biomed Engn, 2126 Lurie Biomed Engn,1101 Beal Ave, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Dept Obstet & Gynecol, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Program Cellular & Mol Biol, Ann Arbor, MI 48109 USA
基金
美国国家科学基金会;
关键词
Fertility preservation; Ovarian tissue cryopreservation; Ovarian follicle culture; Tissue engineering; HUMAN OOCYTE CRYOPRESERVATION; HUMAN PRIMORDIAL FOLLICLES; IN-VITRO CULTURE; GENE-EXPRESSION; LIVE BIRTH; VITRIFICATION; TRANSPLANTATION; GROWTH; SURVIVAL; AUTOTRANSPLANTATION;
D O I
10.1007/s12609-020-00390-z
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose of Review Breast cancer patients who cannot delay treatment or for whom hormone stimulation and egg retrieval are contraindicated require alternative methods of fertility preservation prior to gonadotoxic treatment. Ovarian tissue cryopreservation is an alternative approach that may offer patients the opportunity to preserve fertility and carry biologically related children later in life. Various experimental approaches are being explored to obtain mature gametes from cryopreserved and thawed ovarian tissue for fertilization and implantation using biomimetic tissue culture in vitro. Here, we review the most recent developments in ovarian tissue cryopreservation and exciting advances in bioengineering approaches to in vitro tissue and ovarian follicle culture. Recent Findings Slow freezing is the most widely accepted method for ovarian tissue cryopreservation, but efforts have been made to modify vitrification for this application as well. Numerous approaches to in vitro tissue and follicle culture are in development, most prominently two-step culture systems for ovarian cortical tissue and encapsulation of ovarian follicles in biomimetic matrices for in vitro culture. Refinements to slow freeze and vitrification protocols continue to address challenges associated with cryopreservation, such as ice crystal formation and damage to the stroma. Similarly, improvements to in vitro tissue and follicle culture show promise for utilizing patients' cryopreserved tissues to obtain mature gametes after disease treatment and remission. Development of an effective and reproducible culture system for human ovarian follicles will serve as a broad assisted reproductive technology for cancer survivors who cryopreserved tissue prior to treatment.
引用
收藏
页码:351 / 360
页数:10
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