GLP-1 and the DPP-IV inhibitor saxagliptin similarly protect human beta cells from palmitate-induced toxicity: potential role of autophagy regulation

被引：0
|
作者：
Bugliani, M. [1 ]
Syed, F. [1 ]
Suleiman, M. [1 ]
Olimpico, F. [1 ]
Boggi, U. [1 ]
Masini, M. [1 ]
Masiello, P. [1 ]
Filipponi, F. [1 ]
Marselli, L. [1 ]
Marchetti, P. [1 ]
机构：
[1] Univ Pisa, Islet Cell Lab, Dept Clin & Expt Med, I-56100 Pisa, Italy
来源：
DIABETOLOGIA | 2013年 / 56卷
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
43
引用
收藏
页码：S24 / S24
页数：1
相关论文
共 12 条
  • [1] The DPP-IV inhibitor saxagliptin inhibits palmitate-induced apoptosis of human endothelial cells and cardiac progenitor cells
    Laviola, L.
    Incalza, M.
    Orlando, M. R.
    Caccioppoli, C.
    Leonardini, A.
    D'Oria, R.
    Buccheri, V. Andrulli
    Natalicchio, A.
    Perrini, S.
    Giorgino, F.
    DIABETOLOGIA, 2013, 56 : S70 - S70
  • [2] The DPP-IV Inhibitor Saxagliptin Inhibits Palmitate-Induced Apoptosis of Human Umbilical Vein Endothelial Cells and Human Cardiac Progenitors
    Laviola, Luigi
    Incalza, Maria Angela
    Orlando, Maura R.
    Caccioppoli, Cristina
    Leonardini, Anna
    D'Oria, Rossella
    Buccheri, Valentina Andrulli
    Natalicchio, Annalisa
    Perrini, Sebastio
    Giorgino, Francesco
    DIABETES, 2013, 62 : A128 - A128
  • [3] Comparison of Distinct GLP-1 Receptor Agonists in Palmitate-induced Incretin Resistance of Pancreatic Beta Cells
    Natalicchio, Annalisa
    Biondi, Giuseppina
    Tortosa, Federica
    Labarbuta, Rossella
    Marrano, Nicola
    Cignarelli, Angelo
    Leonardini, Anna
    Perrini, Sebastio
    Laviola, Luigi
    Giorgino, Francesco
    DIABETES, 2015, 64 : A288 - A288
  • [4] A Local GLP-1 System In Human Pancreatic Islets: The Role Of DPP-IV Inhibition by MK-0626
    Bugliani, Marco
    Syed, Farooq
    Suleiman, Mara
    Olimpico, Francesco
    Boggi, Ugo
    Kirkpatrick, Clare
    Wollheim, Claes
    Masini, Matilde
    Masiello, Pellegrino
    Filipponi, Franco
    Marselli, Lorella
    Marchetti, Piero
    DIABETES, 2013, 62 : A96 - A96
  • [5] GLP-1 Receptor Activation Inhibits Palmitate-Induced Apoptosis via Ceramide in Human Cardiac Progenitor Cells
    Leonardini, Anna
    D'Oria, Rossella
    Incalza, Maria Angela
    Caccioppoli, Cristina
    Buccheri, Valentina Andrulli
    Cignarelli, Angelo
    Paparella, Domenico
    Margari, Vito
    Natalicchio, Annalisa
    Perrini, Sebastio
    Giorgino, Francesco
    Laviola, Luigi
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017, 102 (11): : 4136 - 4147
  • [6] Activation of PPARβ/δ protects pancreatic β cells from palmitate-induced apoptosis by upregulating the expression of GLP-1 receptor
    Yang, Yan
    Tong, Yuzhen
    Gong, Meng
    Lu, Yanrong
    Wang, Chengshi
    Zhou, Mingliang
    Yang, Qiu
    Mao, Tingrui
    Tong, Nanwei
    CELLULAR SIGNALLING, 2014, 26 (02) : 268 - 278
  • [7] Pharmacokinetics and pharmacodynamics of SK-0403, a novel DPP-TV inhibitor, in rat:: IC80 for DPP-IV in circulation is insufficient to protect degradation of intact GLP-1
    Furuta, Shinji
    Goto, Moritaka
    Furuta, Yoshiyuki
    Yasuda, Yoshika
    Nakaya, Keizo
    Tamura, Miyuki
    Uesugi, Noriko
    Kawamura, Satoko
    Inoue, Akiharu
    Kato, Noriaki
    Ishida, Tsutomu
    Matsumoto, Yukiharu
    DIABETES, 2007, 56 : A382 - A382
  • [8] The DPP-IV inhibitor linagliptin and GLP-1 induce synergistic effects on body weight loss and appetite suppression in the diet-induced obese rat
    Hansen, Henrik H.
    Hansen, Gitte
    Paulsen, Sarah
    Vrang, Niels
    Mark, Michael
    Jelsing, Jacob
    Klein, Thomas
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 741 : 254 - 263
  • [9] GLP-1 receptor agonist protects palmitate-induced insulin resistance in skeletal muscle cells by up-regulating sestrin2 to promote autophagy
    Tian, Xue
    Gao, Yu
    Kong, Mowei
    Zhao, Lihua
    Xing, Enhong
    Sun, Qitian
    He, Jianqiu
    Lu, Yanan
    Feng, Zengbin
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [10] Role of zonulin and GLP-1/DPP-IV in alleviation of diabetes mellitus by peptide/polypeptide fraction of Aloe vera in streptozotocin- induced diabetic wistar rats
    Babu, Spoorthy N.
    Govindarajan, S.
    Vijayalakshmi, M. A.
    Noor, Ayesha
    JOURNAL OF ETHNOPHARMACOLOGY, 2021, 272
12