Non-Lymphoma Hematological Malignancies in Systemic Lupus Erythematosus

被引：28

作者：

Lu, Mary ^{[1
]}

Bernatsky, Sasha ^{[1
]}

Ramsey-Goldman, Rosalind ^{[6
]}

Petri, Michelle ^{[7
]}

Manzi, Susan ^{[8
]}

Urowitz, Murray B. ^{[2
]}

Gladman, Dafna ^{[2
]}

Fortin, Paul R. ^{[3
,4
]}

Ginzler, Ellen M. ^{[9
]}

Yelin, Edward ^{[10
]}

Bae, Sang-Cheol ^{[15
]}

Wallace, Daniel J. ^{[12
]}

Jacobsen, Soren ^{[17
,18
]}

Dooley, Mary Anne ^{[13
]}

Peschken, Christine A. ^{[5
]}

Alarcon, Graciela S. ^{[14
]}

Nived, Ola ^{[16
]}

Gottesman, Lena ^{[9
]}

Criswell, Lindsey A. ^{[11
]}

Sturfelt, Gunnar ^{[16
]}

Dreyer, Lene ^{[17
,18
]}

Lee, Jennifer L. ^{[1
]}

Clarke, Ann E. ^{[1
]}

机构：

[1] McGill Univ, Div Clin Epidemiol, Ctr Hlth, Montreal, PQ, Canada

[2] Toronto Western Hosp, Dept Rheumatol, Toronto, ON M5T 2S8, Canada

[3] CHU Quebec, Div Rheumatol, Quebec City, PQ, Canada

[4] Univ Laval, Quebec City, PQ, Canada

[5] Univ Manitoba, Dept Rheumatol, Winnipeg, MB, Canada

[6] Northwestern Univ, Feinberg Sch Med, Dept Med Rheumatol, Chicago, IL 60611 USA

[7] Johns Hopkins Univ, Sch Med, Div Rheumatol, Baltimore, MD USA

[8] West Penn Allegheny Hlth Syst, Dept Med, Pittsburgh, PA USA

[9] Suny Downstate Med Ctr, Div Rheumatol, Brooklyn, NY 11203 USA

[10] Univ Calif San Francisco, Div Rheumatol, San Francisco, CA USA

[11] Univ Calif San Francisco, Dept Med, Rosalind Russell Med Res Ctr Arthrit, San Francisco, CA USA

[12] Univ Calif Los Angeles, David Geffen Sch Med, Cedars Sinai Med Ctr, Los Angeles, CA 90095 USA

[13] Univ N Carolina, Dept Rheumatol, Chapel Hill, NC USA

[14] Univ Alabama Birmingham, Dept Rheumatol, Birmingham, AL USA

[15] Hanyang Univ, Hosp Rheumat Dis, Seoul 133791, South Korea

[16] Univ Lund Hosp, Dept Rheumatol, S-22185 Lund, Sweden

[17] Rigshosp, Dept Rheumatol, DK-2100 Copenhagen, Denmark

[18] Copenhagen Univ Hosp, Gentofte Hosp, Copenhagen, Denmark

来源：

ONCOLOGY | 2013年 / 85卷 / 04期

关键词：

Systemic lupus erythematosus; Malignancy; Cancer; MULTIPLE-MYELOMA; AUTOIMMUNE CONDITIONS; RARE ASSOCIATION; PATIENT; DISORDERS; LEUKEMIA;

D O I：

10.1159/000350165

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective: To describe non-lymphoma hematological malignancies in systemic lupus erythematosus (SLE). Methods: A large SLE cohort was linked to cancer registries. We examined the types of non-lymphoma hematological cancers. Results: In 16,409 patients, 115 hematological cancers [including myelodysplastic syndrome (MDS)] occurred. Among these, 33 were non-lymphoma. Of the 33 non-lymphoma cases, 13 were of lymphoid lineage: multiple myeloma (n = 5), plasmacytoma (n = 3), B cell chronic lymphocytic leukemia (B-CLL; n = 3), precursor cell lymphoblastic leukemia (n = 1) and unspecified lymphoid leukemia (n = 1). The remaining 20 cases were of myeloid lineage: MDS (n = 7), acute myeloid leukemia (AML; n = 7), chronic myeloid leukemia (CML; n = 2) and 4 unspecified leukemias. Most of these malignancies occurred in female Caucasians, except for plasma cell neoplasms (4/5 multiple myeloma and 1/3 plasmacytoma cases occurred in blacks). Conclusions: In this large SLE cohort, the most common non-lymphoma hematological malignancies were myeloid types (MDS and AML). This is in contrast to the general population, where lymphoid types are 1.7 times more common than myeloid non-lymphoma hematological malignancies. Most (80%) multiple myeloma cases occurred in blacks; this requires further investigation. (C) 2013 S. Karger AG, Basel

引用

页码：235 / 240

页数：6

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