Component-resolved diagnosis in hymenoptera allergy

被引：15
|
作者：
Antolin-Amerigo, D. [1 ]
Ruiz-Leon, B. [2 ]
Boni, E. [3 ]
Alfaya-Arias, T. [4 ]
Alvarez-Mon, M. [1 ]
Barbarroja-Escudero, J. [1 ]
Gonzalez-de-Olano, D. [5 ]
Moreno-Aguilar, C. [2 ]
Rodriguez-Rodriguez, M. [1 ]
Sanchez-Gonzalez, M. J. [1 ]
Sanchez-Morillas, L. [6 ]
Vega-Castro, A. [7 ]
机构：
[1] Univ Alcala, Hosp Univ Principe Asturias, Dept Med, Serv Enfermedades Sistema Inmune Alergia, Madrid, Spain
[2] Hosp Univ Reina Sofia, Maimonides Biomed Res Inst Cordoba IMIBIC, Serv Alergol, Cordoba, Spain
[3] Hosp Santo Spirito, ASL Alessandria, SS Allergol, Casale Monferrato, AL, Italy
[4] Hosp Gen Univ Ciudad Real, Serv Alergol, Ciudad Real, Spain
[5] Hosp Univ Ramon y Cajal, Serv Alergol, Madrid, Spain
[6] Hosp Clin San Carlos, Serv Alergol, Madrid, Spain
[7] Hosp Univ Guadalajara, Serv Alergol, Guadalajara, Spain
来源：
ALLERGOLOGIA ET IMMUNOPATHOLOGIA | 2018年 / 46卷 / 03期
关键词：
Component resolved diagnosis; Allergy; Hymenoptera; Insect stings; Anaphylaxis; Vespula; Polistes; Apis; Cross-reactivity; API M 1; QUALITY-OF-LIFE; ANTIGENIC CROSS-REACTIVITY; RVES V 5; VENOM ALLERGY; HONEYBEE VENOM; MAJOR ALLERGENS; MELLIFERA VENOM; SYSTEMIC MASTOCYTOSIS; VESPULA VENOM;
D O I：
10.1016/j.aller.2017.05.003
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Component-resolved diagnosis based on the use of well-defined, properly characterised and purified natural and recombinant allergens constitutes a new approach in the diagnosis of venom allergy. Prospective readers may benefit from an up-to-date review on the allergens. The best characterised venom is that of Apis mellifera, whose main allergens are phospholipase A2 (Api ml), hyaluronidase (Api m2) and melittin (Api m4). Additionally, in recent years, new allergens of Vespula vulgaris have been identified and include phospholipase Al (Ves vl), hyaluronidase (Ves v2) and antigen 5 (Ves v5). Polistes species are becoming an increasing cause of allergy in Europe, although only few allergens have been identified in this venom. In this review, we evaluate the current knowledge about molecular diagnosis in hymenoptera venom allergy. (C) 2017 SEICAP. Published by Elsevier Espana, S.L.U. All rights reserved.
引用
收藏
页码：253 / 262
页数：10
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