Development of Mirror-Image Screening Systems for XIAP BIR3 Domain Inhibitors

被引：10
|
作者：
Shu, Keitou [1 ,2 ]
Iwamoto, Naoya [1 ]
Honda, Kaori [3 ]
Kondoh, Yasumitsu [3 ]
Hirano, Hiroyuki [3 ]
Osada, Hiroyuki [3 ]
Ohno, Hiroaki [1 ]
Fujii, Nobutaka [1 ]
Oishi, Shinya [1 ]
机构：
[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan
[2] Kyoto Univ, Grad Sch Adv Integrated Studies Human Survivabil, Sakyo Ku, Kyoto 6068306, Japan
[3] RIKEN, Chem Biol Res Grp, Ctr Sustainable Resource Sci, Wako, Saitama 3510198, Japan
来源：
BIOCONJUGATE CHEMISTRY | 2019年 / 30卷 / 05期
关键词：
D-PEPTIDE INHIBITORS; STRUCTURAL BASIS; APOPTOSIS PROTEIN; NMR STRUCTURE; SH2; DOMAIN; IAP; IDENTIFICATION; SMAC/DIABLO; MUTAGENESIS; ANTAGONIST;
D O I：
10.1021/acs.bioconjchem.9b00154
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The X-linked inhibitor of apoptosis protein baculovirus IAP repeat (XIAP BIR3) domain is a promising therapeutic target for cancer treatment. For the mirror-image screening campaign to identify drug candidates from an unexplored mirror-image natural product library, a facile synthetic protocol for XIAP BIR3 domain synthesis was established by a native chemical ligation strategy using conserved cysteines present among BIR domains. The native and mirror-image XIAP BIR3 domains with an appropriate functional group for labeling were prepared using the established protocol. Taking advantage of the resulting synthetic proteins, several bioassay systems were developed to characterize inhibitors of the protein-protein interaction between the XIAP BIR3 domain and the second mitochondria-derived activator of caspases.
引用
收藏
页码：1395 / 1404
页数：10
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