MER53, a non-autonomous DNA transposon associated with a variety of functionally related defense genes in the human genome

被引：9

作者：

Kapitonov, VV ^{[1
]}

Jurka, J ^{[1
]}

机构：

[1] Genet Informat Res Inst, Palo Alto, CA 94306 USA

来源：

DNA SEQUENCE | 1998年 / 8卷 / 05期

关键词：

interspersed repeat; DNA transposon; mariner; host defense system;

D O I：

10.3109/10425179809034073

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

We report a new medium reiteration frequency repeat MER53 present in human and mammalian genomes. A 189 bp MER53 consensus sequence has been reconstructed based on the computer analysis of GenBank sequences. TA target site duplication and terminal inverted repeats indicate that the MER53 repeat is a non-autonomous DNA transposon related to the mariner family. Two MER53 repeats were found integrated within different mobile elements. We have found that most of the genes harboring the MER53 repeat are involved in the host defense system. The reasons for this Iron-random distribution of the repeat are discussed.

引用

页码：277 / 288

页数：12