Layer-by-layer construction of an oxygen-generating photo-responsive nanomedicine for enhanced photothermal and photodynamic combination therapy

被引：9
|
作者：
Du, Baoji [1 ]
Zhang, Weiqi [1 ]
Tung, Ching-Hsuan [1 ]
机构：
[1] Weill Cornell Med, Dept Radiol, Mol Imaging Innovat Inst, New York, NY 10065 USA
来源：
CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 42期
关键词：
TUMOR HYPOXIA; NANOPARTICLES; CANCER;
D O I：
10.1039/c9cc01461f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A multifunctional photosensitive and photothermal nanomedicine, AMP- Ce6- HA, was prepared by sequentially layering hard and soft functional molecules. AMP- Ce6- HA was efficiently picked up by MDA- MB- 231 breast cancer cells, and then released oxygen in lysosomes. The photothermal and oxygen- enhanced photodynamic combination therapy was much more effective than the single one.
引用
收藏
页码：5926 / 5929
页数：4
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