Epigenetic biomarkers in colorectal cancer: premises and prospects

被引：33

作者：

Zamani, Mozhdeh ^{[1
]}

Hosseini, Seyed Vahid ^{[1
]}

Mokarram, Pooneh ^{[2
,3
]}

机构：

[1] Shiraz Univ Med Sci, Colorectal Res Ctr, Shiraz, Iran

[2] Shiraz Univ Med Sci, Sch Med, Nemazee Hosp, Gasteroenterohepatol Res Ctr, Shiraz, Iran

[3] Shiraz Univ Med Sci, Dept Biochem, Fac Med, Shiraz, Iran

来源：

BIOMARKERS | 2018年 / 23卷 / 02期

关键词：

Colorectal cancer; DNA methylation; miRNA; histone modifications; epigenetics; biomarker; DNA METHYLATION; POOR-PROGNOSIS; PROMOTER METHYLATION; CELL-PROLIFERATION; TUMOR-SUPPRESSOR; DOWN-REGULATION; NONINVASIVE BIOMARKER; HISTONE DEACETYLASES; EXPRESSION PROFILES; CIRCULATING DNA;

D O I：

10.1080/1354750X.2016.1252961

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: Colorectal cancer is one of the most common cancers worldwide. Epigenetic alterations play an important role in the pathogenesis of the colorectal cancer.Objective: This review has focused on the most recent investigations, which has suggested potential epigenetic biomarkers in colorectal cancer.Methods: Evidences were achieved by searching online medical databases including Google scholar, Pubmed, Scopus and Science Direct.Results: Extensive studies have indicated that aberrant epigenetic modifications could serve as potential biomarkers for diagnosis, prognosis and prediction of colorectal cancer.Conclusion: Advances in aberrant epigenetic modifications can open new avenues for exploration of reliable and robust biomarkers to improve the management of CRC patients.

引用

页码：105 / 114

页数：10

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