Epigenetics in Schistosomes: What We know and What We Need know

被引：7

作者：

Liu, Weiwei ^{[1
]}

机构：

[1] Chinese Acad Agr Sci, Shanghai Vet Res Inst, Dept Avian Dis, Shanghai, Peoples R China

来源：

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY | 2016年 / 6卷

关键词：

Schistosome; DNA methylation; histone modifying enzymes; microRNAs; drug discovery; DNA METHYLATION; NONCODING RNAS; CYTOSINE METHYLATION; BIOMPHALARIA-GLABRATA; JAPONICUM INFECTION; HISTONE H2B; HOST SERUM; MICRORNAS; MANSONI; GENOME;

D O I：

10.3389/fcimb.2016.00149

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Schistosomes are metazoan parasites and can cause schistosomiasis. Epigenetic modifications include DNA methylation, histone modifications and non-coding RNAs. Some enzymes involved in epigenetic modification and microRNA processes have been developed as drugs to treat the disease. Compared with humans and vertebrates, an in-depth understanding of epigenetic modifications in schistosomes is starting to be realized. DNA methylation, histone modifications and non-coding RNAs play important roles in the development and reproduction of schistosomes and in interactions between the host and schistosomes. Therefore, exploring and investigating the epigenetic modifications in schistosomes will facilitate drug development and therapy for schistosomiasis. Here, we review the role of epigenetic modifications in the development, growth and reproduction of schistosomes, and the interactions between the host and schistosome. We further discuss potential epigenetic targets for drug discovery for the treatment of schistosomiasis.

引用

页数：9

共 50 条

[1] Epigenetics in ecology and evolution: what we know and what we need to know INTRODUCTION
Verhoeven, Koen J. F.
Vonholdt, Bridgett M.
Sork, Victoria L.
[J]. MOLECULAR ECOLOGY, 2016, 25 (08) : 1631 - 1638
[2] What we know, what we don't know and what we need to know
Chapple, Christopher R.
MacNeil, Sheila
[J]. CURRENT OPINION IN UROLOGY, 2019, 29 (04) : 378 - 379
[3] Diversity: What We Know, What We Need to Know, and What We Need to Do
Dukes, Charles
Lamar-Dukes, Pamela
[J]. RESEARCH AND PRACTICE FOR PERSONS WITH SEVERE DISABILITIES, 2009, 34 (3-4) : 71 - 75
[4] From Linkage Studies to Epigenetics: What We Know and What We Need to Know in the Neurobiology of Schizophrenia
Cariaga-Martinez, Ariel
Saiz-Ruiz, Jeronimo
Alelu-Paz, Raul
[J]. FRONTIERS IN NEUROSCIENCE, 2016, 10
[5] Re: What we Know, What we Don't Know and What we Need to Know
Wein, Alan J.
[J]. JOURNAL OF UROLOGY, 2020, 203 (06): : 1068 - 1068
[6] Political Simulations: What We Know, What We Think We Know, and What We Still Need to Know
Baranowski, Michael K.
Weir, Kimberly A.
[J]. JOURNAL OF POLITICAL SCIENCE EDUCATION, 2015, 11 (04) : 391 - 403
[7] Bronchial thermoplasty: what we know, what we don't know, and what we need to know
Russell, Richard J.
Brightling, Christopher E.
[J]. EUROPEAN RESPIRATORY JOURNAL, 2022, 59 (01)
[8] Syphilis and blood donors: What we know, what we do not know, and what we need to know
Orton, S
[J]. TRANSFUSION MEDICINE REVIEWS, 2001, 15 (04) : 282 - 291
[9] Population and consumption - What we know, what we need to know
Kates, RW
[J]. ENVIRONMENT, 2000, 42 (03): : 10 - 19
[10] Outcomes in CKD: What We Know and What We Need to Know
Clark, Laura E.
Khan, Izhar
[J]. NEPHRON CLINICAL PRACTICE, 2010, 114 (02): : C95 - C102

← 1 2 3 4 5 →