Second-trimester maternal pregnancy-associated plasma protein A and inhibin A levels in fetal trisomies

被引：6

作者：

Watanabe, H ^{[1
]}

Hamada, H ^{[1
]}

Yamada, N ^{[1
]}

Ogura, T ^{[1
]}

Yasuoka, MO ^{[1
]}

Okuno, S ^{[1
]}

Fujiki, Y ^{[1
]}

Sohda, S ^{[1
]}

Kubo, T ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Obstet & Gynecol, Tsukuba, Ibaraki 3058575, Japan

来源：

FETAL DIAGNOSIS AND THERAPY | 2002年 / 17卷 / 03期

关键词：

pregnancy-associated plasma protein A; inhibin A; fetal trisomy; second trimester;

D O I：

10.1159/000048026

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The aim of this study was to determine whether fetal trisomy is associated with altered levels of seeond-trimester maternal pregnancy-associated plasma protein A (PAPP-A) and inhibin A. Methods: Maternal serum PAPP-A and inhibin A concentrations were measured at 15-17 weeks of gestation in 14 singleton pregnancies with fetal trisomy and in 56 matched pregnant controls. Results: PAPP-A levels in the trisomy group were significantly lower than in controls. The inhibin A level with fetal trisomy 21 was slightly higher than the control group, but levels were not different between trisomies 18 and 13 and controls. Conclusion: Fetal trisomies 21, 18, and 13 are associated with a reduction in second-trimester maternal PAPP-A levels; trisomies 18 and 13 are not associated with increased inhibin A levels, unlike trisomy 21.

引用

页码：137 / 141

页数：5

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