Ligament Tissue Engineering and Its Potential Role in Anterior Cruciate Ligament Reconstruction

被引：22

作者：

Yates, E. W. ^{[1
]}

Rupani, A. ^{[2
]}

Foley, G. T. ^{[1
]}

Khan, W. S. ^{[3
,4
]}

Cartmell, S. ^{[2
]}

Anand, S. J. ^{[1
]}

机构：

[1] Stepping Hill Hosp, Stockport NHS Fdn Trust, Dept Trauma & Orthopaed, Stockport SK2 7JE, Lancs, England

[2] Univ Manchester, Ctr Mat Sci, Manchester M13 9PT, Lancs, England

[3] Royal Natl Orthopaed Hosp, Stanmore HA7 4LP, Middx, England

[4] Univ Coll London, Inst Orthopaed & Musculoskeletal Sci, Stanmore HA7 4LP, Middx, England

来源：

STEM CELLS INTERNATIONAL | 2012年 / 2012卷

关键词：

MESENCHYMAL STEM-CELLS; BONE-MARROW; SILK SCAFFOLD; STROMAL CELLS; IN-VIVO; TENDON; FIBROBLASTS; DIFFERENTIATION;

D O I：

10.1155/2012/438125

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Tissue engineering is an emerging discipline that combines the principle of science and engineering. It offers an unlimited source of natural tissue substitutes and by using appropriate cells, biomimetic scaffolds, and advanced bioreactors, it is possible that tissue engineering could be implemented in the repair and regeneration of tissue such as bone, cartilage, tendon, and ligament. Whilst repair and regeneration of ligament tissue has been demonstrated in animal studies, further research is needed to improve the biomechanical properties of the engineered ligament if it is to play an important part in the future of human ligament reconstruction surgery. We evaluate the current literature on ligament tissue engineering and its role in anterior cruciate ligament reconstruction.

引用

页数：6

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