TYK2-STAT1 Pathway Positively Regulates BCL2 Gene Expression in T-Cell Acute Lymphoblastic Leukemia

被引:0
|
作者
Sanda, Takaomi
Tyner, Jeffrey W. [1 ]
Gutierrez, Alejandro
Ngo, Vu N. [2 ]
Glover, Jason M. [1 ]
Chang, Bill H. [1 ]
Yost, Arla J. [3 ]
Weng, Andrew P. [4 ]
Ma, Wenxue [5 ]
Tatarek, Jessica [6 ]
Fleischman, Angela G. [1 ]
Ahn, Yebin
Yang, Yandan
Zhou, Wenjun [7 ]
Neuberg, Donna S. [8 ]
Moriggl, Richard [9 ]
Mueller, Mathias [10 ]
Kelliher, Michelle [11 ]
Jamieson, Catriona
Gray, Nathanael S.
Staudt, Louis M. [12 ]
Druker, Brian J. [1 ]
Look, Thomas
机构
[1] Oregon Hlth & Sci Univ, Knight Canc Inst, Portland, OR 97201 USA
[2] City Hope Natl Med Ctr, Div Hematopoiet Stem Cell & Leukemia Res, Duarte, CA USA
[3] BC Canc Agcy, Terry Fox Lab, Vancouver, BC, Canada
[4] British Columbia Canc Agcy, Terry Fox Lab, Vancouver, BC V5Z 1L3, Canada
[5] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA
[6] UMass Med Sch, Worcester, MA USA
[7] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
[8] Dana Farber Canc Inst, Dept Biostat & Computat Biol, Boston, MA 02115 USA
[9] Ludwig Boltzmann Inst Canc Res, Vienna, Austria
[10] Univ Vet Med Vienna, Dept Biomed Sci, Vienna, Austria
[11] Univ Massachusetts, Sch Med, Worcester, MA USA
[12] NCI, Metab Branch, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1182/blood.V120.21.1470.1470
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
1470
引用
收藏
页数:2
相关论文
共 50 条
  • [1] TYK2-STAT1-BCL2 Pathway Dependence in T-cell Acute Lymphoblastic Leukemia
    Sanda, Takaomi
    Tyner, Jeffrey W.
    Gutierrez, Alejandro
    Ngo, Vu N.
    Glover, Jason
    Chang, Bill H.
    Yost, Arla
    Ma, Wenxue
    Fleischman, Angela G.
    Zhou, Wenjun
    Yang, Yandan
    Kleppe, Maria
    Ahn, Yebin
    Tatarek, Jessica
    Kelliher, Michelle A.
    Neuberg, Donna S.
    Levine, Ross L.
    Moriggl, Richard
    Mueller, Mathias
    Gray, Nathanael S.
    Jamieson, Catriona H. M.
    Weng, Andrew P.
    Staudt, Louis M.
    Druker, Brian J.
    Look, A. Thomas
    CANCER DISCOVERY, 2013, 3 (05) : 564 - 577
  • [2] The TYK2-STAT1 pathway in aggressive T-Cell Lymphoma: A new therapeutic intervention site?
    Prutsch, N.
    Sanda, T.
    Wu, L.
    Turner, S.
    Jaeger, U.
    Staber, P.
    Steinberger, P.
    Moriggl, R.
    Mueller, M.
    Kenner, L.
    Merkel, O.
    ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 239 - 239
  • [3] Pathway Dependence on the Tyrosine Kinase TYK2 and Its Mediator STAT1 In T-Cell Acute Lymphoblastic Leukemia
    Sanda, Takaomi
    Tyner, Jeffrey W.
    Gutierrez, Alejandro
    Ngo, Vu N.
    Moriggl, Richard
    Ahn, Yebin
    Glover, Jason M.
    Chang, Bill H.
    Willis, Stephanie G.
    Staudt, Louis M.
    Druker, Brian J.
    Look, A. Thomas
    BLOOD, 2010, 116 (21) : 1298 - 1298
  • [4] Pathway dependence on the tyrosine kinase TYK2 in T-cell acute lymphoblastic leukemia
    Sanda, Takaomi
    Tyner, Jeffrey W.
    Gutierrez, Alejandro
    Ngo, Vu N.
    Moriggl, Richard
    Ahn, Yebin
    Glover, Jason
    Chang, Bill H.
    Willis, Stephanie G.
    Zhou, Wenjun
    Gray, Nathanael S.
    Staudt, Louis M.
    Druker, Brian J.
    Look, A. Thomas
    CANCER RESEARCH, 2011, 71
  • [5] RNAi Screen Reveals TYK2 as a Novel Therapeutic Gene Target In T-Cell Acute Lymphoblastic Leukemia
    Tyner, Jeffrey W.
    Sanda, Takaomi
    Gutierrez, Alejandro
    Glover, Jason M.
    Chang, Bill H.
    Willis, Stephanie G.
    Ahn, Yebin
    Look, A. Thomas
    Druker, Brian J.
    BLOOD, 2010, 116 (21) : 441 - 441
  • [6] Leukemia inhibitory factor stimulates vascular calcification through TYK2-STAT1/3 pathway activation
    Alesutan, I.
    Pitigala, L.
    Luong, T. T.
    Estepa, M.
    Zickler, D.
    Pasch, A.
    Holfeld, J.
    Vlahou, A.
    Eckardt, K. -U.
    Voelkl, J.
    ACTA PHYSIOLOGICA, 2022, 236 : 541 - 541
  • [7] Gene expression profiling in T-cell acute lymphoblastic leukemia
    Ferrando, AA
    Look, AT
    SEMINARS IN HEMATOLOGY, 2003, 40 (04) : 274 - 280
  • [8] ABT-199 MEDIATED INHIBITION OF BCL2 AS A NOVEL THERAPEUTIC STRATEGY IN T-CELL ACUTE LYMPHOBLASTIC LEUKEMIA
    Peirs, S.
    Matthijssens, F.
    Goossens, S.
    De Bock, C.
    Cante-Barrett, K.
    Lammens, T.
    Van de Walle, I.
    De Moerloose, B.
    Benoit, Y.
    Poppe, B.
    Taghon, T.
    Cools, J.
    Meijerink, J.
    Soulier, J.
    Speleman, F.
    Van Vlierberghe, P.
    HAEMATOLOGICA, 2014, 99 : 539 - 540
  • [9] STAT5 does not drive steroid resistance in T-cell acute lymphoblastic leukemia despite the activation of BCL2 and BCLXL following glucocorticoid treatment
    Zwet, Jordy C. G. van der
    Cordo, Valentina
    Buijs-Gladdines, Jessica G. C. A. M.
    Hagelaar, Rico
    Smits, Willem K.
    Vroegindeweij, Eric
    Graus, Laura T. M.
    Poort, Vera M.
    Nulle, Marloes
    Pieters, Rob
    Meijerink, Jules P. P.
    HAEMATOLOGICA, 2023, 108 (03) : 732 - 746
  • [10] TLE1 Gene Expression in Adult T-Cell Acute Lymphoblastic Leukemia
    Elbaiomy, Mohamed
    Sabry, Mohamed
    Aref, Salah
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S273 - S273