Carbenoid-mediated N-O bond insertion and its application in the synthesis of pyridines

被引：12
|
作者：
Qi, Xinxin [1 ]
Dai, Lu [1 ]
Park, Cheol-Min [1 ]
机构：
[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore
来源：
CHEMICAL COMMUNICATIONS | 2012年 / 48卷 / 91期
关键词：
DE-NOVO SYNTHESIS; DIELS-ALDER REACTION; ONE-POT SYNTHESIS; DERIVATIVES; CYCLOADDITION; ALKYNES; 1,2,4-TRIAZINES; ISOQUINOLINES; CYCLIZATION; ACETYLENES;
D O I：
10.1039/c2cc36009h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly efficient synthesis of 3-hydroxypyridines has been developed based on carbenoid-mediated N-O bond insertion. Treatment of delta-diazo oxime ethers with dirhodium complex Rh-2(tfacam)(4) rapidly provides a variety of pyridines in 5-10 minutes in good to excellent yields.
引用
收藏
页码：11244 / 11246
页数：3
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