Efficient synthesis of fluorophosphonylated alkyles by ring-opening reaction of cyclic sulfates

被引：21

作者：

Diab, Sonia Amel ^{[1
]}

Sene, Aboubacary ^{[1
]}

Pfund, Emmanuel ^{[1
]}

Lequeux, Thierry ^{[1
]}

机构：

[1] Univ Caen Bosse Normandie, CNRS, Lab Chim Mol & Thioorgan, ENSICAEN,UMR 6507, F-14050 Caen, France

来源：

ORGANIC LETTERS | 2008年 / 10卷 / 17期

关键词：

D O I：

10.1021/ol801443s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ring-opening reactions of functionalized 1,2-cyclic sulfates and oxetanes with the phosphonodifluoromethyl carbanion are reported. This approach allows an easy access to fluorinated beta-hydroxyphosphonates that are building blocks in the synthesis of acyclic nucleosides. Synthesis of precursors of nucleoside phosphorylase inhibitors from these alcohols is described.

引用

页码：3895 / 3898

页数：4

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