A phase II study evaluating KN026 monotherapy in patients (pts) with previously treated, advanced HER2-expressing gastric or gastroesophageal junction cancers (GC/GEJC).

被引：0
|
作者：
Xu, Jianming
Liu, Rongrui
Ying, Jieer
Wu, Jun
Ye, Feng
Xu, Nong
Zhang, Yanqiao
Zhao, Rusen
Xiang, Xiaojun
Wang, Jianhong
Lin, Xiaoyan
Xu, Huiting
Gao, Shegan
Luo, Suxia
Guo, Baohong
Li, Xionghui
Su, Yangzhi
Wang, Qian
机构：
[1] Peoples Liberat Army Gen Hosp, Dept Gastrointestinal Oncol, Med Ctr 5, Beijing, Peoples R China
[2] Chinese Peoples Liberat Army Gen Hosp, Dept Gastrointestinal Oncol, Med Ctr 5, Beijing, Peoples R China
[3] Univ Chinese Acad Sci, Chinese Acad Sci, Inst Canc & Basic Med IBMC, Canc Hosp,Zhejiang Canc Hosp,Dept Hepato Pancreat, Hangzhou, Peoples R China
[4] First Peoples Hosp Changzhou, Dept Oncol, Changzhou, Peoples R China
[5] Xiamen Univ, Affiliated Hosp 1, Dept Med Oncol, Xiamen, Peoples R China
[6] Zhejiang Univ, Affiliated Hosp 1, Dept Med Oncol, Sch Med, Hangzhou, Peoples R China
[7] Harbin Med Univ Canc Hosp, Dept Gastrointestinal Med Oncol, Harbin, Peoples R China
[8] Zibo Municipal Hosp, Dept Med Oncol, Zibo, Peoples R China
[9] Nanchang Univ, Affiliated Hosp 1, Dept Oncol, Nanchang, Jiangxi, Peoples R China
[10] Nantong Tumor Hosp, Dept Med Oncol, Nantong, Peoples R China
[11] Fujian Med Univ Union Hosp, Dept Med Oncol, Fuzhou, Peoples R China
[12] Hubei Canc Hosp, Dept Med Oncol, Wuhan, Peoples R China
[13] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Med Oncol, Luoyang, Peoples R China
[14] Zhengzhou Univ, Affiliated Canc Hosp, Zhengzhou, Peoples R China
[15] Henan Canc Hosp, Zhengzhou, Peoples R China
[16] Alphamab Oncol Ltd, Suzhou, Peoples R China
[17] Alphamab Oncol Ltd, Suzhou, Peoples R China
[18] CSPC Zhongqi Pharmaceut Technol Shijiazhuang Co L, Dept Med, Shijiazhuang, Hebei, Peoples R China
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2022年 / 40卷 / 16期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
4040
引用
收藏
页数：1
相关论文
共 50 条
  • [1] KN026 (anti-HER2 bispecific antibody) in patients with previously treated, advanced HER2-expressing gastric or gastroesophageal junction cancer
    Xu, Jianming
    Ying, Jieer
    Liu, Rongrui
    Wu, Jun
    Ye, Feng
    Xu, Nong
    Zhang, Yanqiao
    Zhao, Rusen
    Xiang, Xiaojun
    Wang, Jianhong
    Lin, Xiaoyan
    Xu, Huiting
    Gao, Shegan
    Luo, Suxia
    Guo, Baohong
    Li, Xionghui
    Su, Yangzhi
    Wang, Qian
    [J]. EUROPEAN JOURNAL OF CANCER, 2023, 178 : 1 - 12
  • [2] The preliminary efficacy of KN026 (Anti-HER2 BsAb) in advanced gastric and gastroesophageal junction cancer patients with HER2 expression.
    Xu, Jianming
    Zhang, Yun
    Wu, Jun
    Xu, Nong
    Ying, Jieer
    Xiang, Xiaojun
    Zhang, Yanqiao
    Wang, Jianhong
    Zhao, Rusen
    Ye, Feng
    Wu, Qiong
    Guo, Baohong
    Liu, Yuchen
    Liu, Juan
    Xing, Shuning
    Xu, Ting
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [3] The preliminary efficacy and safety of KN026 combined with KN046 treatment in HER2-positive locally advanced unresectable or metastatic gastric/gastroesophageal junction cancer without prior systemic treatment in a phase II study
    Shen, L.
    Gong, J.
    Niu, Z.
    Zhao, R.
    Chen, L.
    Liu, L.
    Deng, T.
    Lu, L.
    Zhang, Y.
    Li, Z.
    Li, X.
    Xia, B.
    [J]. ANNALS OF ONCOLOGY, 2022, 33 (07) : S1102 - S1102
  • [4] Phase II pharmacokinetic (PK) and pharmacodynamic (PD) study of OSI-7904L in previously untreated patients (pts) with advanced gastric or gastroesophageal junction cancer (G/GEJC).
    Falk, SJ
    Anthoney, A
    Eatock, M
    van Cutsem, E
    Evans, J
    Valle, J
    Chick, J
    Drolet, D
    Ferry, D
    Ajani, J
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) : 318S - 318S
  • [5] Phase I trial of SHR-A1811 in HER2-expressing advanced gastric cancer (GC) or gastroesophageal junction adenocarcinoma (GEJ) and colorectal cancer (CRC)
    Li, J.
    Luo, S.
    Liu, T.
    Dong, L.
    Yuan, X.
    Feng, J.
    Wang, Y.
    Deng, Y.
    Chen, J.
    Zhang, M.
    Zhou, H.
    Cao, Y.
    Qiu, W.
    Ren, X.
    Cai, S.
    Dong, Y.
    Wang, W.
    Shen, Y.
    Dou, N.
    Huang, C.
    [J]. ANNALS OF ONCOLOGY, 2023, 34 : S478 - S478
  • [6] Phase II study of taxotere monotherapy in previously treated patients (pts) with advanced breast cancer (ABC)
    Alexopoulos, CG
    Rigatos, G
    Efremidou, A
    Papacharalambous, A
    Alexopoulos, A
    Vasilomanolakis, M
    Patila, E
    [J]. EUROPEAN JOURNAL OF CANCER, 1997, 33 : 680 - 680
  • [7] A phase II study of tivantinib monotherapy in patients with previously treated advanced or recurrent gastric cancer
    Muro, Kei
    Ryu, Min-Hee
    Yasui, Hirofumi
    Nishina, Tomohiro
    Ryoo, Baek-Yeol
    Boku, Narikazu
    Kang, Yoon-Koo
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (15)
  • [8] Safety and Efficacy of Pembrolizumab Monotherapy in Patients With Previously Treated Advanced Gastric and Gastroesophageal Junction Cancer Phase 2 Clinical KEYNOTE-059 Trial
    Fuchs, Charles S.
    Doi, Toshihiko
    Jang, Raymond W.
    Muro, Kei
    Satoh, Taroh
    Machado, Manuela
    Sun, Weijing
    Jalal, Shadia I.
    Shah, Manish A.
    Metges, Jean-Phillipe
    Garrido, Marcelo
    Golan, Talia
    Mandala, Mario
    Wainberg, Zev A.
    Catenacci, Daniel V.
    Ohtsu, Atsushi
    Shitara, Kohei
    Geva, Ravit
    Bleeker, Jonathan
    Ko, Andrew H.
    Ku, Geoffrey
    Philip, Philip
    Enzinger, Peter C.
    Bang, Yung-Jue
    Levitan, Diane
    Wang, Jiangdian
    Rosales, Minori
    Dalal, Rita P.
    Yoon, Harry H.
    [J]. JAMA ONCOLOGY, 2018, 4 (05)
  • [9] Concordance of HER2 Status between Local and Central Review in Gastric (GC) and gastroesophageal Junction Cancers (GEJC): A French Observational Study of 394 Specimens: HERable Study
    Doucet, Laurent
    Terris, Benoit
    Chenard, Marie-Pierre
    Bibeau, Frederic
    Penault-Llorca, Frederique
    Bougrini, Mouna
    Fraga, Emmanuele Conde da Silva
    Monges, Genevieve
    [J]. LABORATORY INVESTIGATION, 2016, 96 : 170A - 170A
  • [10] Concordance of HER2 Status between Local and Central Review in Gastric (GC) and gastroesophageal Junction Cancers (GEJC): A French Observational Study of 394 Specimens: HERable Study
    Doucet, Laurent
    Terris, Benoit
    Chenard, Marie-Pierre
    Bibeau, Frederic
    Penault-Llorca, Frederique
    Bougrini, Mouna
    Fraga, Emmanuele Conde Da Silva
    Monges, Genevieve
    [J]. MODERN PATHOLOGY, 2016, 29 : 170A - 170A
12345