Orphanin FQ reduces morphine-induced dopamine release in the nucleus accumbens: a microdialysis study in rats

被引：74
|
作者：
Di Giannuario, A [1 ]
Pieretti, S [1 ]
Catalani, A [1 ]
Loizzo, A [1 ]
机构：
[1] Ist Super Sanita, Farmacol Lab, I-00161 Rome, Italy
来源：
NEUROSCIENCE LETTERS | 1999年 / 272卷 / 03期
关键词：
orphanin; nociceptin; morphine; microdialysis; dopamine; nucleus accumbens;
D O I：
10.1016/S0304-3940(99)00579-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effects induced by orphanin FQ (OFQ) on morphine-induced dopamine (DA), 3,4-dihydroxyphenilacetic acid (DOPAC) and homovanillic acid (HVA) release in the nucleus accumbens were studied in rats by using microdialysis with electrochemical detection. Morphine administered intraperitoneally (i.p., 2, 5 and 10 mg/kg) dose-dependently increased DA and metabolites release in the nucleus accumbens. OFQ intracerebroventricularly (i.c.v.) administered at doses of 2, 5 and 10 nmol did not change DA and metabolites release in the nucleus accumbens. OFQ (10 nmol) administered i.c.v. 15 min before morphine (5 and 10 mg/kg, i.p.) significantly reduced morphine-induced DA and metabolites release in the nucleus accumbens. These effects suggest that OFQ may regulate the stimulant action linked to morphine-induced DA release in the nucleus accumbens. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：183 / 186
页数：4
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