Self-assembly of an amphiphilic derivative of chitosan and micellar solubilization of puerarin

被引：39

作者：

Sui, WP ^{[1
]}

Yin, CQ ^{[1
]}

Chen, YJ ^{[1
]}

Zhang, ZG ^{[1
]}

Kong, XZ ^{[1
]}

机构：

[1] Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2006年 / 48卷 / 01期

关键词：

self-assemble; chitosan; solubilization; micelle; puerarin;

D O I：

10.1016/j.colsurfb.2006.01.005

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

A kind of amphiphilic derivatives of chitosan (2-hydroxyl-3-butoxyl)-propylcarboxymethyl-chitosan (HBP-CMCHS), has been synthesized, and the critical micelle concentration (cmc) of HBP-CMCHS was detected by the fluorescence method. The puerarin-loaded HBP-CMCHS micellar system was prepared by physical entrapped method. Result showed that when adding the same amount of puerarin, the solubilizing capacity was enhanced by increasing the concentration of HBP-CMCHS and temperature. Puerarin-loaded micellar system of HBP-CMCHS was characterized by TEM and DLS. TEM photograph revealed that the micelles were spherical and puerarin was solubilized in the cores of the spherical polymeric micelles. DLS showed that after solubilization the size of the micelles became bigger. In vitro tests showed that puerarin was slowly released from micellar solution and the release lasted up to 60 h by means of the dialysis method. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：13 / 16

页数：4

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