Psychiatric symptoms in adults with phenylketonuria

被引：45

作者：

Bilder, Deborah A. ^{[1
]}

Burton, Barbara K. ^{[2
,3
]}

Coon, Hilary ^{[4
]}

Leviton, Lauren ^{[2
]}

Ashworth, James ^{[1
]}

Lundy, Bridget D. ^{[5
]}

Vespa, Hazel ^{[2
]}

Bakian, Amanda V. ^{[1
]}

Longo, Nicola ^{[5
]}

机构：

[1] Univ Utah, Sch Med, Dept Psychiat, Div Child & Adolescent Psychiat, Salt Lake City, UT 84108 USA

[2] Ann & Robert H Lurie Childrens Hosp Chicago, Chicago, IL USA

[3] Northwestern Univ, Feinberg Sch Med, Chicago, IL 60611 USA

[4] Univ Utah, Sch Med, Dept Psychiat, Salt Lake City, UT 84108 USA

[5] Univ Utah, Sch Med, Dept Pediat, Div Med Genet, Salt Lake City, UT 84108 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2013年 / 108卷 / 03期

关键词：

Phenylketonuria; Chronic illness; Psychiatric; Assessment; Psychosis; EARLY-TREATED PHENYLKETONURIA; WHITE-MATTER ABNORMALITIES; PSYCHOLOGICAL DISTRESS; WORKING-MEMORY; YOUNG-WOMEN; CHILDREN; PKU; ADOLESCENTS; DISORDERS; BEHAVIOR;

D O I：

10.1016/j.ymgme.2012.12.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The objective of this study was to identify psychiatric symptom patterns reported by individuals with phenylketonuria (PKU) in the outpatient clinic setting. Methods: Brief Symptom Inventory (BSI) results, phenylalanine (phe) levels, and demographic information were collected through a retrospective chart review on 64 participants in the study, "A Diversified Approach for PKU Treatment" (ADAPT). Results: The number of BSI scores meeting clinical threshold was significantly elevated for all global indexes and 6 out of 7 symptom subscales in patients with PKU. Recent and mean phe levels were correlated with age at the time of screening (R-2=0.10, R-2=0.10, respectively; p < 0.05). Psychoticism and the Positive Symptom Distress Index (PSDI) scores were associated with metabolic control. Conclusions: The results of this study demonstrate a positive correlation between phe levels and psychiatric symptom severity in individuals with PKU. (C) 2013 Elsevier Inc. All rights reserved.

引用

页码：155 / 160

页数：6

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