Effects of subchronic exposure to atrazine on zebrafish (Danio rerio)

被引：20
|
作者：
Plhalova, L. [1 ]
Blahova, J. [1 ]
Mikulikova, I. [1 ]
Stepanova, S. [1 ]
Dolezelova, P. [1 ]
Praskova, E. [1 ]
Marsalek, P. [1 ]
Skoric, M. [2 ]
Pistekova, V. [1 ]
Bedanova, I. [1 ]
Svobodova, Z. [1 ]
机构：
[1] Univ Vet & Pharmaceut Sci Brno, Fac Vet Hyg & Ecol, Dept Vet Publ Hlth & Toxicol, Brno 61242, Czech Republic
[2] Univ Vet & Pharmaceut Sci Brno, Fac Vet Med, Dept Pathol Morphol, Brno 61242, Czech Republic
来源：
POLISH JOURNAL OF VETERINARY SCIENCES | 2012年 / 15卷 / 03期
关键词：
Zebrafish; growth test; histopathology; triazine herbicide; FRESH-WATER; HERBICIDE ATRAZINE; RESPONSES; TOXICITY; TRIAZINE; GROWTH; MODEL; GILL;
D O I：
10.2478/v10181-012-0065-8
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The aim of this study was to investigate the effects of subchronic exposure to atrazine on fish growth and the development of histopathological changes in selected organs (gill, kidney, liver) in Danio rerio. Juvenile growth tests were performed on D. rerio according to OECD method No. 215. For 28 days, fish at an initial age of 30 days were exposed to the environmental atrazine concentration commonly detected in Czech rivers (0.3 mu g/L) and a range of sublethal concentrations of atrazine (3.0, 30.0 and 90.0 mu g/L). The results showed decreasing growth rates and morphological changes in the liver (dystrophic lesions of hepatocytes) at 90.0 mu g/L of atrazine. The environmental concentration of atrazine in Czech rivers did not have any effect on fish growth and development of histopathological changes in D. rerio. The value of NOEC was 30.0 mu g/L and the value of LOEC was 90.0 mu g/L.
引用
收藏
页码：417 / 423
页数：7
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