Long-term follow-up of initial trabeculectomy with mitomycin C for primary open-angle glaucoma in Japanese patients

被引:66
|
作者
Shigeeda, Takashi
Tomidokoro, Atsuo
Chen, Yi-Ning
Shirato, Shiroaki
Araie, Makoto
机构
[1] Univ Tokyo, Grad Sch Med, Dept Ophthalmol, Bunkyo Ku, Tokyo 1138655, Japan
[2] Yotsuya Shirato Eye Clin, Tokyo, Japan
关键词
mitomycin C; primary open-angle glaucoma; trabeculectomy;
D O I
10.1097/01.ijg.0000212202.57029.45
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Purpose: To determine the long-term intraocular pressure (IOP) control and postoperative complications after initial trabeculectomy with use of mitomycin C (MMC) in patients with primary open-angle glaucoma (POAG). Patients and Methods: A retrospective review was conducted of a consecutive series of 123 eyes (87 patients) with POAG who underwent initial trabeculectomy with MMC and had at least 4 years of follow-up. All patients underwent standard trabeculectomy with 0.04% MMC applied intraoperatively for 3 minutes. The long-term outcomes (IOP control of and bleb leak, long-standing hypotony, bleb-related infections) were analyzed with the Kaplan-Meier life-table method on the basis of three definitions of successful IOP control (defined as IOP < 18 mmHg (definition 1), IOP < 16 mmHg (definition 2), and IOP decrease of by 30% and < 21 mmHg (definition 3)). Results: The mean follow-up time was 6.8 +/- 1.4 (mean SD) years. The cumulative survival rates were 67.0 +/- 4.6%, 44.5 +/- 5.4%, and 74.1 +/- 4.2%, respectively, based on definitions 1, 2, and 3, 8 years postoperatively by life-table analysis. At 8 years, bleb leak occurred in 7.9 +/- 2.6% of eyes, long-standing hypotony in 8.3 +/- 2.5%, and bleb-related infections in 5.9 +/- 2.4%. Conclusion: Long-term outcome after initial trabeculectomy with MMC in Japanese POAG patients is comparable with that reported in other populations and with that after trabeculectomy with 5-fluorouracil.
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页码:195 / 199
页数:5
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