CORRELATION OF BLOOD SERUM TRANSPORT PROTEIN CONTENT OF IMMUNOGLOBULINS OF M, G, A AND E CLASS WITH THE LEVEL OF IMMUNE RESPONSE IN INHABITANTS OF THE ARCTIC ZONE OF THE RUSSIAN FEDERATION

The paper presents the results of studying of the relationship of serum immunoglobulins (Ig) content of classes M, G, A and E with the level of immune response in residents of the Arctic zone of the Russian Federation. It was found that the average concentration of IgM, IgA and IgE in the peripheral venous blood of the Arctic residents was higher by 1.5-2 times, the registration frequency of elevated levels was higher by 2.4-8.6 times than of the people living in more favorable climatic conditions. Activation of autosensitization processes in Arctic residents is accompanied by a high frequency of recording of increased concentrations of autoantibodies to leukocytes, erythrocytes, ds-DNA, RNP, cardiolipin, oLDL at 10.41-57.14%. In the conditions of the Arctic a significant excessthe concentrations of CIC with IgM and IgA than the complexes with IgG, which indirectly confirms the activation of preventive inflammation responses and the more significant binding ability of secretory antibodies. The increase concentrations of IgM and IgA of the Arctic residents are associated with a decrease in cell-mediated cytotoxicity and with the increase in the level of IFN-gamma, sCD71, which increases the efficiency clearance of waste product in hypoxic conditions.