Detection of Human Papillomavirus in Clinical Samples

被引：25

作者：

Westra, William H. ^{[1
,2
,3
]}

机构：

[1] Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA

[2] Johns Hopkins Med Inst, Dept Oncol, Baltimore, MD 21205 USA

[3] Johns Hopkins Med Inst, Dept Otolaryngol Head & Neck Surg, Baltimore, MD 21205 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2012年 / 45卷 / 04期

关键词：

Oropharyngeal carcinoma; Squamous cell carcinoma of the head and neck; In situ hybridization; Hybrid capture 2; p16; immunohistochemistry; SQUAMOUS-CELL CARCINOMA; IN-SITU HYBRIDIZATION; FINE-NEEDLE-ASPIRATION; HYBRID CAPTURE 2; NECK-CANCER; OROPHARYNGEAL CANCER; 16-NEGATIVE HEAD; TUMOR-ORIGIN; HPV DNA; P16(INK4A);

D O I：

10.1016/j.otc.2012.04.001

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

The confirmation of human papillomavirus (HPV) as a causative agent for a subset of squamous cell carcinomas of the head and neck has resulted in a growing expectation for HPV testing in head and neck cancers. An increasing understanding of HPV-related tumorigenesis has informed this evaluation process in a manner that is moving wide scale, indiscriminant, and nonstandardized testing toward a more directed, clinically relevant, and standardized approach. This review addresses the current state of HPV detection and focuses on the importance, appropriate time, and need for HPV testing.

引用

页码：765 / +

页数：14

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