Primary hyperparathyroidism with duodenal ulcer and H-pylori infection

被引：3
|
作者：
Sato, H [1 ]
Abe, K [1 ]
Oshima, N [1 ]
Kawashima, K [1 ]
Hamamoto, N [1 ]
Moritani, M [1 ]
Mak, R [1 ]
Ishihara, S [1 ]
Adachi, K [1 ]
Kawauchi, H [1 ]
Kinoshita, Y [1 ]
机构：
[1] Shimane Med Univ, Dept Internal Med 2, Izumo, Shimane 6938501, Japan
来源：
INTERNAL MEDICINE | 2002年 / 41卷 / 05期
关键词：
gastric pH; Helicobacter pylori; hypercalcemia;
D O I：
10.2169/internalmedicine.41.377
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A patient with duodenal ulcer and primary hyperparathyroidism was found to have an abnormally high intragastric pH. The pH level returned to normal after surgical removal of the parathyroid adenoma followed by normalization of parathyroid hormone (PTH) and serum calcium concentrations. The patient was positive for Helicobacter pylori (H. pylori) infection. Although the exact mechanism by which chronic hypercalcemia or high PTH level inhibited gastric acid secretion in this case remains unclear, our findings suggest that hypercalcemia may play some role in H. pylori associated gastroduodenal diseases through induction of proinflammatory cytokines or by enhancing the attachment of H. pylori to gastric epithelial cells.
引用
收藏
页码：377 / 380
页数：4
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