Copper-catalyzed oxidative sp3 C-H bond arylation with aryl boronic acids

被引：159
|
作者：
Basle, Olivier [1 ]
Li, Chao-Jun [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 17期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1021/ol8012588
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient method was developed for arylation of sp(3) C-H bonds using copper bromide as catalyst in absence of directing group with arylboronic acids. The oxidative arylation provides easy access to biologically active tetrahydroisoquinoline derivatives and can either use peroxide or molecular oxygen as oxidant.
引用
收藏
页码：3661 / 3663
页数：3
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