Pathogenesis of Exercise-Induced Bronchoconstriction

被引：31
|
作者：
Kippelen, Pascale [1 ]
Anderson, Sandra D. [2 ]
机构：
[1] Brunel Univ, Ctr Sports Med & Human Performance, Uxbridge UB8 3PH, Middx, England
[2] Royal Prince Alfred Hosp, Dept Resp & Sleep Med, Camperdown, NSW 2050, Australia
来源：
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2013年 / 33卷 / 03期
关键词：
Hyperpnoea; Osmotic stress; Thermal stress; Epithelial injury; Airway inflammation; EXHALED BREATH CONDENSATE; AIRWAY SMOOTH-MUSCLE; INDUCED ASTHMA; INDUCED BRONCHOSPASM; BRONCHIAL HYPERRESPONSIVENESS; EPITHELIAL DAMAGE; COLD-AIR; RESPIRATORY SYMPTOMS; IPRATROPIUM BROMIDE; INSPIRED AIR;
D O I：
10.1016/j.iac.2013.02.002
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
This article presents the various potential mechanisms responsible for the development of exercise-induced bronchoconstriction (EIB). Although the etiology of EIB is multifactorial, and the physiologic processes involved may vary between individuals (especially between those with and without asthma), drying of the small airways with an associated inflammatory response seems prerequisite for EIB. Dysregulated repair processes following exercise-induced airway epithelial injury may also serve as basis for EIB development/progression.
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页码：299 / +
页数：15
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