Metal-based antitumor compounds: beyond cisplatin

被引：99

作者：

Simpson, Peter V. ^{[1
]}

Desai, Nima Maheshkumar ^{[2
]}

Casari, Ilaria ^{[2
]}

Massi, Massimiliano ^{[1
]}

Falasca, Marco ^{[2
]}

机构：

[1] Curtin Univ, Curtin Inst Funct Mol & Interfaces, Dept Chem, Kent St, Bentley, WA 6102, Australia

[2] Curtin Univ, Curtin Hlth Innovat Res Inst, Sch Pharm & Biomed Sci, Metab Signalling Grp, Perth, WA 6102, Australia

来源：

FUTURE MEDICINAL CHEMISTRY | 2019年 / 11卷 / 02期

关键词：

cancer; chemoresistance; chemotherapy; cisplatin; metal-based anticancer agents; VITRO ANTICANCER ACTIVITY; CANCER-CELLS; COPPER-COMPLEXES; ORGANOMETALLIC COMPOUNDS; PHOTODYNAMIC THERAPY; MOLECULAR-STRUCTURE; RHENIUM COMPLEXES; PROSTATE-CANCER; NITRIC-OXIDE; IV COMPLEX;

D O I：

10.4155/fmc-2018-0248

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Despite improvements in the 5-year survival rate to over 80% in cancers, such as Hodgkin lymphoma and testicular cancer, more aggressive tumors including pancreatic and brain cancer still have extremely low survival rates. The establishment of chemoresistance, responsible for the reduction in treatment efficiency and cancer relapse, is one possible explanation for this setback. Metal-based compounds, a class of anticancer drugs, are largely used in the treatment of cancer. Herein, we will review the use of metal-based small molecules in chemotherapy, focusing on recent studies, and we will discuss how new nonplatinum-based agents are prompting scientists to increase drug specificity to overcome chemoresistance in cancer cells.

引用

页码：119 / 135

页数：17

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