Synthesis and antimicrobial activities of some new 1,2,4-triazole derivatives

The triazole nucleus is one of the most important and well known heterocycle which is a common and integral feature of a variety of natural products and medicinal agents. The wide spectrum of antimicrobial, antiviral and potent pharmacological activities of triazole and their derivatives has established them as medicinally significant scaffolds. In view of these reports and in continuation of the search for triazole derivatives with better antimicrobial activities, herein is reported the synthesis and antimicrobial activities of some new triazole derivatives with biologically active sulphonamide moiety at the 3rd position. The structures of the newly synthesised compounds have been established on the basis of their spectrochemical data and elemental analysis. All the compounds have been screened for antimicrobial activities against Escherichia coli, Bacillus cirroflagellosus, Aspergillus niger and Colletotrichum capsici by cup plate method using Cotrimoxazole and Diflucan as standards.