Determination of finasteride in the tablet form by liquid chromatography and its analytical method validation

被引：9
|
作者：
Demir, H [1 ]
Cucu, A [1 ]
Sakarya, S [1 ]
机构：
[1] Marmara Univ, Fac Pharm, TR-81010 Istanbul, Turkey
来源：
ANALYTICA CHIMICA ACTA | 2006年 / 557卷 / 1-2期
关键词：
finasteride; Dilaprost (R); validation;
D O I：
10.1016/j.aca.2005.10.033
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A quantitative method for finasteride by liquid chromatography (LC) with UV detector, was validated for its new tablet form Dilaprost (R). Analysis was performed using Nova Pak C-18 column at 60 degrees C. Detection was carried out at a wavelength of 210 nm. The best separation for finasteride peak was achieved by isocratic elution with the mobile phase water/acetonitrile/tetrahydrofuran (80/10/10, v/v/v) and flow rate of 2 mL min(-1). The sample volume injected into liquid chromatography system was 15 mu L. Analytical method validation tests were performed. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：252 / 255
页数：4
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