An Evidence-Based and Practical Approach to Using Bydureon™ in Patients With Type 2 Diabetes

被引：25
|
作者：
Painter, Nathan A. [1 ]
Morello, Candis M. [1 ,2 ]
Singh, Renu F. [1 ]
McBane, Sarah E. [1 ]
机构：
[1] Univ Calif San Diego, Sch Pharm & Pharmaceut Sci, San Diego, CA 92103 USA
[2] Vet Affairs San Diego Healthcare Syst, San Diego, CA USA
来源：
JOURNAL OF THE AMERICAN BOARD OF FAMILY MEDICINE | 2013年 / 26卷 / 02期
关键词：
Chronic Disease; Diabetes Mellitus; Drugs; Evidence-based Medicine; Pharmacology; Pharmacotherapy; OPEN-LABEL; EXENATIDE; EFFICACY; SAFETY; PIOGLITAZONE; SITAGLIPTIN; FORMULATION; METFORMIN; WEIGHT;
D O I：
10.3122/jabfm.2013.02.120174
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Glucagon-like peptide (GLP)-1 agonists are one of the newer classes of medications for use in type 2 diabetes. There are currently three GLP-1 agonists on the market: exenatide twice daily, liraglutide, and exenatide extended release (ER). Exenatide ER is a new weekly formulation of exenatide. Exenatide ER reduces glycosylated hemoglobin by 1.6%, with fewer gastrointestinal side effects compared with twice-daily exenatide. Like other GLP-1 agonists, exenatide ER can be used in combination with metformin, sulfonylureas, or thiazolidinediones. Patients should be assessed for risk of pancreatitis and renal impairment. Education about proper administration technique is vital with the novel delivery system. Prescribers may also consider the use of exenatide ER to improve medication adherence in patients who have successfully tolerated exenatide twice daily or use in patients who have gastrointestinal side effects with exenatide twice daily. Exenatide is a reasonable option that can be added to the regimen of a patient with type 2 diabetes. (J Am Board Fam Med 2013; 26:203-210.)
引用
收藏
页码：203 / 210
页数：8
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