Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells

被引：39
|
作者：
Yang, Ling [1 ]
Li, Hongyan [1 ]
Jiang, Yizhou [1 ]
Zuo, Ji [1 ]
Liu, Wen [1 ]
机构：
[1] Fudan Univ, Dept Cellular & Genet Med, Sch Basic Med Sci, Shanghai 200032, Peoples R China
来源：
CANCER LETTERS | 2013年 / 336卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Mortalin; Ovarian cancer; Drug-resistance; Apoptosis; Sensitivity; GLUCOSE DEPRIVATION; P53; ASSOCIATION; CONTRIBUTES; APOPTOSIS; PI3K/AKT;
D O I：
10.1016/j.canlet.2013.05.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The heat shock protein mortalin is frequently overexpressed in human malignancies. In this study, an assessment of mortalin expression using ovarian cancer tissue microarrays suggested that mortalin overexpression might be related to drug resistance. Using a short hairpin (sh) RNA approach, we evaluated the effect of reducing mortalin expression in vitro and in vivo. The results of our study show that elevated levels of mortalin expression increase cancer cell resistance to cisplatin-induced cytotoxicity and identify mortalin as a potential therapeutic target for improved treatment of drug-resistant ovarian cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：213 / 221
页数：9
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