The new HPLC methodology for the chiral separation of tamsulosin enantiomers on amylose tris(3,5-dimethylphenylcarbamate) stationary phase

被引：2
|
作者：
Kantor-Boruta, Malgorzata [2 ]
Lisowska-Kuzmicz, Malgorzata [2 ]
Jonczyk, Anna [2 ]
Siedlecka, Joanna [2 ]
Ocios-Bebenek, Agnieszka [2 ]
Jaronczyk, Malgorzata [2 ]
Mazurek, Aleksander P. [2 ,3 ]
Ksycinska, Hanna [4 ]
Chilmonczyk, Zdzislaw [2 ]
Jarosz, Maciej [1 ]
机构：
[1] Warsaw Univ Technol, Fac Chem, Chair Analyt Chem, PL-00664 Warsaw, Poland
[2] Natl Med Inst, PL-00725 Warsaw, Poland
[3] Med Univ Warsaw, Fac Pharm, PL-02097 Warsaw, Poland
[4] Pharmaceut Res Inst, PL-01793 Warsaw, Poland
来源：
TALANTA | 2012年 / 102卷
关键词：
Tamsolusin; Chiral separation; HPLC; Enantiomers; Amylose tris(3,5-dimethylphenylcarbamate); ISOMERS;
D O I：
10.1016/j.talanta.2012.06.004
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
New chromatographic method for the enantioseparation of (R,S)-tamsulosin and the determination of (R)- and (S)-tamsulosin was developed with the aid of amylose tris(3,5-dimethylphenylcarbamate) stationary phase. The method was compared to the known procedure for tamsulosin enantioseparation on cellulose tris(3,5-dimethylphenyl carbamate). Careful validation of both methods allowed to prove advantages of the new procedure: significantly better resolution as well as twice better sensitivity. The method was applied to quantification of (R)- and (S)-tamsulosin contents in prolonged release Apo-Tamis 0.4 mg hard capsules (Apotex Europe B.V) and Omnic Ocas 0.4 mg coated tablets (Astellas). (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：75 / 78
页数：4
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